Ethnobotany and the role of plant natural products in antibiotic drug discovery
The crisis of antibiotic resistance necessitates creative and innovative approaches, from
chemical identification and analysis to the assessment of bioactivity. Plant natural products …
chemical identification and analysis to the assessment of bioactivity. Plant natural products …
[HTML][HTML] New tuberculosis drug targets, their inhibitors, and potential therapeutic impact
The current tuberculosis (TB) predicament poses numerous challenges and therefore every
incremental scientific work and all positive socio-political engagements, are steps taken in …
incremental scientific work and all positive socio-political engagements, are steps taken in …
Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H) …
X Li, V Hernandez, FL Rock, W Choi… - Journal of medicinal …, 2017 - ACS Publications
There is an urgent need to develop new and safer antitubercular agents that possess a
novel mode of action. We synthesized and evaluated a novel series of 3-aminomethyl 4 …
novel mode of action. We synthesized and evaluated a novel series of 3-aminomethyl 4 …
The struggle to end a millennia-long pandemic: novel candidate and repurposed drugs for the treatment of tuberculosis
BD Edwards, SK Field - Drugs, 2022 - Springer
This article provides an encompassing review of the current pipeline of putative and
developed treatments for tuberculosis, including multidrug-resistant strains. The review has …
developed treatments for tuberculosis, including multidrug-resistant strains. The review has …
Challenging the drug-likeness dogma for new drug discovery in tuberculosis
D Machado, M Girardini, M Viveiros… - Frontiers in …, 2018 - frontiersin.org
The emergence of multi-and extensively drug resistant tuberculosis worldwide poses a great
threat to human health and highlight the need to discover and develop new, effective and …
threat to human health and highlight the need to discover and develop new, effective and …
Optimizing cardio, hepato and phospholipidosis toxicity of the Bedaquiline by chemoinformatics and molecular modelling approach
The FDA granted expedited approval for Johnson and Johnson's Bedaquiline to treat
pulmonary multidrug resistant tuberculosis on 28 December 2012 which is more common in …
pulmonary multidrug resistant tuberculosis on 28 December 2012 which is more common in …
S2k-Leitlinie: Tuberkulose im Erwachsenenalter
T Schaberg, T Bauer, F Brinkmann, R Diel… - …, 2017 - thieme-connect.com
In Deutschland ist seit 2015 ein deutlicher Anstieg der gemeldeten Tuberkulosefälle zu
verzeichnen. Zurückzuführen ist dieser vor allem auf die aktuell vermehrte Migration. Durch …
verzeichnen. Zurückzuführen ist dieser vor allem auf die aktuell vermehrte Migration. Durch …
Improved treatment outcomes with bedaquiline when substituted for second-line injectable agents in multidrug-resistant tuberculosis: a retrospective cohort study
Background Bedaquiline is used as a substitute for second-line injectable (SLI) intolerance
in the treatment of multidrug-resistant (MDR) tuberculosis, but the efficacy and safety of this …
in the treatment of multidrug-resistant (MDR) tuberculosis, but the efficacy and safety of this …
Targeting bacterial energetics to produce new antimicrobials
From the war on drug resistance, through cancer biology, even to agricultural and
environmental protection: there is a huge demand for rapid and effective solutions to control …
environmental protection: there is a huge demand for rapid and effective solutions to control …
Chemical classes presenting novel antituberculosis agents currently in different phases of drug development: A 2010–2020 review
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a curable airborne
disease currently treated using a drug regimen consisting of four drugs. Global TB control …
disease currently treated using a drug regimen consisting of four drugs. Global TB control …