Abstract PI3K/AKT signaling leads to reduced apoptosis, stimulates cell growth and
increases proliferation. Under normal conditions, PI3K/AKT activation is tightly controlled …

In recent years, microRNAs (miRNAs) have been identified as mediators of tumour
suppression and stress responses exerted by the p53 tumour suppressor. p53-regulated …

Colorectal cancer (CRC) is one of the leading causes of cancer and cancer-related mortality
worldwide. The disease has been traditionally a major health problem in industrial countries …

microRNAs (miRNAs) are non coding RNAs with different biological functions and
pathological implications. Given their role as post-transcriptional gene expression …

Pancreatic cancer (PC) is the fourth most common cause of death among all cancers. Poor
prognosis of PC may be caused by a prevalence of cancer stem cells (CSCs). CSCs are a …

Summary Downregulation of the miR-143/145 microRNA (miRNA) cluster has been
repeatedly reported in colon cancer and other epithelial tumors. In addition, overexpression …

Colorectal cancer (CRC) is the third most common cancer and leading cause of cancer
related deaths worldwide. Despite recent advancements in surgical and molecular targeted …

Abstract miR-143 and miR-145 are co-expressed microRNAs (miRNAs) that have been
extensively studied as potential tumor suppressors. These miRNAs are highly expressed in …

Rationale: In the microenvironment of atherosclerotic lesions, vascular smooth muscle cells
(vSMCs) switch to a dedifferentiated state but the underlying molecular mechanisms driving …

Micro RNA s are endogenous, small (18–25 nucleotides) non‐coding RNA s, which regulate
genes expression by directly binding to the 3′‐untranslated regions of the target …