MicroRNAs (miRNAs) are small noncoding RNAs, approximately 18–25 nucleotides in
length, now recognized as one of the major regulatory gene families in eukaryotes. Recent …

Genetic and epigenetic modifications in DNA contribute to altered gene expression in aging
and cancer. In human cancers, epigenetic changes such as DNA methylation, histone …

Ferroptosis is a regulated form of cell death driven by small molecules or conditions that
induce lipid-based reactive oxygen species (ROS) accumulation. This form of iron …

Objective Distant metastasis is the major cause of cancer-related death in patients with
colorectal cancer (CRC). Although the microRNA-200 (miR-200) family is a crucial inhibitor …

Activation of oncogenes or the deactivation of tumor suppressor genes has long been
established as the fundamental mechanism leading towards carcinogenesis. Although this …

During the last decade, it has become clear that aberrant microRNA expression has a
functional role in the initiation and progression of colorectal cancer (CRC). Specific …

MicroRNAs (miRNAs) are recognized as being central players in many biological processes
and cellular pathways. Their roles in disease have been highlighted first by observation of …

MicroRNAs (miRNAs) represent an important class of small regulatory RNAs that control
gene expression posttranscriptionally by targeting mRNAs for degradation or translation …

In the early years of the molecular biology revolution, cancer research was mainly focused
on genetic changes (ie, those that altered DNA sequences). Although this has been …

Objectives: The main objective of this study was to investigate the potential use of circulating
microRNAs (miRNAs) as biomarkers of sporadic colorectal cancer (CRC). Background …