The calcium-sensing receptor (CaR) is responsive to changes in the extracellular Ca2+
(Ca2+ o) concentration. It is a member of the largest family of cell surface receptors, the G …

Background Breast cancer subtypes identified in genomic studies have different underlying
genetic defects. Mutations in the tumor suppressor p53 occur more frequently in estrogen …

The extracellular calcium-sensing receptor (CaR) plays a key role in the defense against
hypercalcemia by “sensing” extracellular calcium (Ca2+ o) levels in the parathyroid and …

Deeper mechanistic understanding of non-small cell lung cancer (NSCLC), a leading cause
of total cancer-related deaths, may facilitate the establishment of more effective therapeutic …

The prognosis of breast cancer patients is related to the degree of metastasis. However, the
mechanisms by which epithelial tumor cells escape from the primary tumor and colonize at a …

Defective mitotic spindles or an impaired spindle–kinetochore interaction activates the
spindle checkpoint. We have previously shown that BubR1 haplo-insufficiency results in …

Background MicroRNAs (miRNAs) can act as either oncogenes or tumor suppressor genes
under different conditions and thus can play a significant role in cancer development. We …

Human securin, pituitary tumor transforming gene (PTTG), is a protooncogene. Here we
report expressions of PTTG and its interacting protein, PTTG-binding factor in human …

Teleost fish genome projects involving model species are resulting in a rapid accumulation
of genomic and expressed DNA sequences in public databases. The expressed sequence …

The extracellular calcium-sensing receptor (CaR) is a versatile 'sensor'for di-and
polycationic molecules in the body. CaR plays a key role in the defense against …