Genetic mosaicism in the human brain: from lineage tracing to neuropsychiatric disorders
S Bizzotto, CA Walsh - Nature Reviews Neuroscience, 2022 - nature.com
Genetic mosaicism is the result of the accumulation of somatic mutations in the human
genome starting from the first postzygotic cell generation and continuing throughout the …
genome starting from the first postzygotic cell generation and continuing throughout the …
Taming transposable elements in livestock and poultry: a review of their roles and applications
Livestock and poultry play a significant role in human nutrition by converting agricultural by-
products into high-quality proteins. To meet the growing demand for safe animal protein …
products into high-quality proteins. To meet the growing demand for safe animal protein …
Crossroads between transposons and gene regulation
Transposons are mobile genetic elements that have made a large contribution to genome
evolution in a largely species-specific manner. A wide variety of different transposons have …
evolution in a largely species-specific manner. A wide variety of different transposons have …
Comprehensive profiling of L1 retrotransposons in mouse
X Zhang, I Celic, H Mitchell, S Stuckert… - Nucleic Acids …, 2024 - academic.oup.com
L1 elements are retrotransposons currently active in mammals. Although L1s are typically
silenced in most normal tissues, elevated L1 expression is associated with a variety of …
silenced in most normal tissues, elevated L1 expression is associated with a variety of …
Genomics-guided drawing of molecular and pathophysiological components of malignant regulatory signatures reveals a pivotal role in human diseases of stem cell …
GV Glinsky - Frontiers in Oncology, 2021 - frontiersin.org
Repetitive DNA sequences (repeats) colonized two-third of human genome and a majority of
repeats comprised of transposable genetic elements (TE). Evolutionary distinct categories of …
repeats comprised of transposable genetic elements (TE). Evolutionary distinct categories of …
Mapping of long interspersed element-1 (L1) insertions by TIPseq provides information about sub chromosomal genetic variation in human embryos
Purpose Retrotransposons play important roles during early development when they are
transiently de-repressed during epigenetic reprogramming. Long interspersed element-1 …
transiently de-repressed during epigenetic reprogramming. Long interspersed element-1 …
Transposon insertion profiling by sequencing (TIPseq) identifies novel LINE-1 insertions in human sperm
Purpose Long interspersed nuclear element-1 (LINE-1 or L1) comprises 17% of the human
genome. Retrotransposons may perturb gene integrity or alter gene expression by altering …
genome. Retrotransposons may perturb gene integrity or alter gene expression by altering …
SINGLE CELL TIPSEQ, A NEW METHOD TO MAP LINE-1 INSERTIONS, PROVIDES INFORMATION ABOUT SUB CHROMOSOMAL GENETIC VARIATION IN …
Objective One third of euploid embryo transfers fail, implicating sub-chromosomal genetic
variation. Retrotransposons play important roles during early development, when they are …
variation. Retrotransposons play important roles during early development, when they are …