The potential therapeutic effect of statins in multiple sclerosis: beneficial or detrimental effects

HM Al-Kuraishy, AI Al-Gareeb, HM Saad… - …, 2023 - Springer
Multiple sclerosis (MS) is a chronic progressive disabling disease of the central nervous
system (CNS) characterized by demyelination and neuronal injury. Dyslipidemia is observed …

Connecting the dots between hypercholesterolemia and Alzheimer's disease: a potential mechanism based on 27-hydroxycholesterol

M Wu, Y Zhai, X Liang, W Chen, R Lin, L Ma… - Frontiers in …, 2022 - frontiersin.org
Alzheimer's disease (AD), the most common cause of dementia, is a complex and
multifactorial disease involving genetic and environmental factors, with …

[HTML][HTML] Neuroprotective role of astaxanthin in hippocampal insulin resistance induced by Aβ peptides in animal model of Alzheimer's disease

SO Rahman, BP Panda, S Parvez, M Kaundal… - Biomedicine & …, 2019 - Elsevier
With the constant failure of the clinical trials continuous exploration of a therapeutic target
against Alzheimer's disease (AD) is the utmost need. Numerous studies have supported the …

Sphingosine-1-phosphate receptor 1 activation in the central nervous system drives cisplatin-induced cognitive impairment

S Squillace, ML Niehoff, TM Doyle… - The Journal of …, 2022 - Am Soc Clin Investig
Cancer-related cognitive impairment (CRCI) is a major neurotoxicity affecting more than
50% of cancer survivors. The underpinning mechanisms are mostly unknown, and there are …

Linagliptin, a DPP-4 inhibitor, ameliorates Aβ (1− 42) peptides induced neurodegeneration and brain insulin resistance (BIR) via insulin receptor substrate-1 (IRS-1) in …

N Siddiqui, J Ali, S Parvez, S Zameer, AK Najmi… - …, 2021 - Elsevier
Alzheimer's disease (AD) is the most devastating neurodegenerative disorder, accounting
over 46 million cases of dementia globally. Evidence supports that Brain Insulin Resistance …

Dexmedetomidine attenuates neuroinflammation in LPS-stimulated BV2 microglia cells through upregulation of miR-340

Y Bao, Y Zhu, G He, H Ni, C Liu, L Ma… - Drug Design …, 2019 - Taylor & Francis
Background Dexmedetomidine (Dex) was reported to exhibit anti-inflammatory effect in the
nervous system. However, the mechanism by which Dex exhibits anti-inflammation effects …

Multifaceted neuroprotective role of Punicalagin: a review

N Siddiqui, A Saifi, A Chaudhary, PN Tripathi… - Neurochemical …, 2024 - Springer
Millions of people worldwide are currently afflicted with neurologic conditions like a seizure,
depression, stress, Alzheimer's disease, Parkinson's disease, and Huntington's disease …

A potent and selective CXCR2 antagonist improves neuroimmune dysregulation through the inhibition of NF-κB and notch inflammatory signaling in the BTBR mouse …

HA Alomar, MA Ansari, A Nadeem, SM Attia… - Journal of …, 2023 - Elsevier
Autism comprises a broad range of neurodevelopmental disorders characterized by social
communication deficits and repetitive and stereotyped behaviors. Chemokine receptor …

In silico interactions of natural and synthetic compounds with key proteins involved in Alzheimer's disease: prospects for designing new therapeutics compound

ME Shah-Abadi, A Ariaei, F Moradi… - Neurotoxicity …, 2023 - Springer
Memory impairment is a result of multiple factors including amyloid-beta (Aβ) accumulation.
Several receptors are mediated for Aβ transport and signaling. Moreover, blood lipids are …

Global loss of acetylcholinesterase activity with mitochondrial complexes inhibition and inflammation in brain of hypercholesterolemic mice

R Paul, A Borah - Scientific reports, 2017 - nature.com
There exists an intricate relationship between hypercholesterolemia (elevated plasma
cholesterol) and brain functions. The present study aims to understand the impact of …