Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …

Diversity and plasticity are two hallmarks of macrophages. M1 macrophages (classically
activated macrophages) are pro-inflammatory and have a central role in host defense …

Somatic mutations in blood indicative of clonal hematopoiesis of indeterminate potential
(CHIP) are associated with an increased risk of hematologic malignancy, coronary artery …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Atherosclerosis is commonly looked upon as a chronic inflammatory disease of the arterial
wall arising from an unbalanced lipid metabolism and a maladaptive inflammatory response …

Experimental models of atherosclerosis suggest that recruitment of monocytes into plaques
drives the progression of this chronic inflammatory condition. Cholesterol-lowering therapy …

The basic biology of the cell division cycle and its control by protein kinases was originally
studied through genetic and biochemical studies in yeast and other model organisms. The …

Reactive oxygen species (ROS) are key signaling molecules that regulate vascular function
and structure in physiological conditions. A misbalance between the production and …

Atherosclerosis is a progressive chronic disease of large and medium arteries,
characterized by the formation of atherosclerotic plaques. Monocytes and macrophages are …

Abstract Toll-like receptor (TLR) 2, TLR4 and CD36 are central in inflammation and the
development of atherosclerosis. Oxidized low-density lipoprotein (oxLDL) plays a critical …