The cingulum bundle is a prominent white matter tract that interconnects frontal, parietal, and
medial temporal sites, while also linking subcortical nuclei to the cingulate gyrus. Despite its …

Depression is a syndrome of stress-and emotion-dysregulation, involving compromised
structural integrity of frontal-limbic networks. Meta-analytic evidence indicates that volumetric …

Alterations in white matter (WM) microstructure have been implicated in the pathophysiology
of major depressive disorder (MDD). However, previous findings have been inconsistent …

Finding robust brain substrates of mood disorders is an important target for research. The
degree to which major depression (MDD) and bipolar disorder (BD) are associated with …

Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the
pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies …

The Hierarchical Taxonomy of Psychopathology (HiTOP) is a quantitative nosological
system that addresses shortcomings of traditional mental disorder diagnoses, including …

Bipolar disorder (BD) is a leading cause of global disability. Its biological basis is unknown,
and its treatment unsatisfactory. Here, we review two recent areas of progress. First, the …

Major depressive disorder (MDD), anxiety disorders (ANX), and chronic pain (CP) are
closely-related disorders with both high degrees of comorbidity among them and shared risk …

Distinguishing depression in bipolar disorder (BD) from unipolar depression (UD) solely
based on clinical clues is difficult, which has led to the exploration of promising neural …

Major depression is associated with altered static functional connectivity in various brain
networks, particularly the default mode network (DMN). Dynamic functional connectivity is a …