Ischemic heart disease is the most common cause of lethal ventricular arrhythmias and
sudden cardiac death (SCD). In patients who are at high risk after myocardial infarction …

Heart failure (HF) is associated with elevated sympathetic tone and mechanical load. Both
systems activate signaling transduction pathways that increase cardiac output, but …

Key points Ventricular arrhythmias are a major complication after myocardial infarction (MI),
associated with sympathetic activation. The structurally heterogeneous peri‐infarct zone is a …

Background and Objectives: Enhanced beat-to-beat variability of ventricular repolarization
(BVR) has been linked to arrhythmias and sudden cardiac death. Recent experimental …

The ryanodine receptor type 2 (RyR) is a key player in Ca 2+ handling during excitation-
contraction coupling. During each heartbeat, RyR channels are responsible for linking the …

Short-term variability (STV), to quantify beat-to-beat variability of repolarization, is a
surrogate parameter that reliably identifies proarrhythmic risk in preclinical models …

Current inotropic agents in heart failure therapy associate with low benefit and significant
adverse effects, including ventricular arrhythmias. Istaroxime, a novel Na+/K+-transporting …

Introduction To study the conditions leading to the initiation and termination of drug induced
Torsade de pointes (TdP) along with QT prolongation. Methods A 2D anisotropic transmural …

Objective: Elevated spatio-temporal variability of human ventricular repolarization has been
related to increased risk for ventricular arrhythmias and sudden cardiac death, particularly …

We analyzed role of cardiac α 1-adrenoreceptors for the torsadogenic action of I Kr blocker
nifekalant in isoflurane-anesthetized atrioventricular block rabbits. Bradycardia was induced …