Organ transplantation is undergoing profound changes. Contraindications for donation have
been revised in order to better meet the organ demand. The use of lower-quality organs and …

Organ preservation and re‐conditioning using machine perfusion technologies continue to
generate promising results in terms of viability assessment, organ utilization and improved …

Vascular endothelial cells (ECs) play a central role in the pathophysiology of many
diseases. The use of targeted nanoparticles (NPs) to deliver therapeutics to ECs could …

The influence of erythrocytes and oxygen concentration on kidneys during long-term
normothermic kidney perfusion is under debate. This study compares acellular and …

The endothelial glycocalyx is a thin layer consisting of proteoglycans, glycoproteins and
glycosaminoglycans that lines the luminal side of vascular endothelial cells. It acts as a …

The lack of suitable kidney donor organs has led to rising numbers of patients with end
stage renal disease waiting for kidney transplantation. Despite decades of clinical …

The volume of oxygen drawn from systemic capillaries down a partial pressure gradient is
determined by the oxygen content of red blood cells (RBCs) and their oxygen-unloading …

Extracellular vesicles (EVs) play an important role in cell-to-cell communication by delivering
coding and non-coding RNA species and proteins to target cells. Recently, the therapeutic …

Ex-situ normothermic machine perfusion (NMP) of transplant kidneys allows assessment of
kidney quality and targeted intervention to initiate repair processes prior to transplantation …

Since the beginning of transplant medicine in the 1950s, advances in surgical technique
and immunosuppressive therapy have created the success story of modern organ …