Current advances in ligand design for inorganic positron emission tomography tracers 68 Ga, 64 Cu, 89 Zr and 44 Sc

TW Price, J Greenman, GJ Stasiuk - Dalton transactions, 2016 - pubs.rsc.org
A key part of the development of metal based Positron Emission Tomography probes is the
chelation of the radiometal. In this review the recent developments in the chelation of four …

[HTML][HTML] PET-MR and SPECT-MR multimodality probes: Development and challenges

CT Yang, KK Ghosh, P Padmanabhan, O Langer… - Theranostics, 2018 - ncbi.nlm.nih.gov
Positron emission tomography (PET)-magnetic resonance (MR) or single photon emission
computed tomography (SPECT)-MR hybrid imaging is being used in daily clinical practice …

Horizons of nanotechnology applications in female specific cancers

B Rajitha, RR Malla, R Vadde, P Kasa… - Seminars in cancer …, 2021 - Elsevier
Female-specific cancers are the most common cancers in women worldwide. Early detection
methods remain unavailable for most of these cancers, signifying that most of them are …

In vivo PET imaging of the cancer integrin αvβ6 using 68Ga-labeled cyclic RGD nonapeptides

J Notni, D Reich, OV Maltsev, TG Kapp… - Journal of Nuclear …, 2017 - Soc Nuclear Med
Expression of the cellular transmembrane receptor αvβ6 integrin is essentially restricted to
malignant epithelial cells in carcinomas of a broad variety of lineages, whereas it is virtually …

Continued rapid growth in 68Ga applications: update 2013 to June 2014

I Velikyan - Journal of Labelled Compounds and …, 2015 - Wiley Online Library
The worldwide utilization of 68Ga‐radionuclide for the fundamental research and clinical
applications is growing exponentially. A broad range of 68Ga‐based imaging agents has …

A shortcut to high-affinity Ga-68 and Cu-64 radiopharmaceuticals: one-pot click chemistry trimerisation on the TRAP platform

Z Baranyai, D Reich, A Vágner, M Weineisen… - Dalton …, 2015 - pubs.rsc.org
Due to its 3 carbonic acid groups being available for bioconjugation, the TRAP chelator (1,
4, 7-triazacyclononane-1, 4, 7-tris (methylene (2-carboxyethylphosphinic acid))) is chosen …

Phosphinic acid functionalized polyazacycloalkane chelators for radiodiagnostics and radiotherapeutics: unique characteristics and applications

J Notni, J Šimeček, HJ Wester - ChemMedChem, 2014 - Wiley Online Library
Given the wide application of positron emission tomography (PET), positron‐emitting metal
radionuclides have received much attention recently. Of these, gallium‐68 has become …

Expanding PET-applications in life sciences with positron-emitters beyond fluorine-18

HH Coenen, J Ermert - Nuclear medicine and biology, 2021 - Elsevier
Abstract Positron-emission-tomography (PET) has become an indispensable diagnostic tool
in modern nuclear medicine. Its outstanding molecular imaging features allow repetitive …

Manganese in PET imaging: Opportunities and challenges

M Brandt, J Cardinale, I Rausch… - Journal of Labelled …, 2019 - Wiley Online Library
Several radionuclides of the transition metal manganese are known and accessible. Three
of them, 51Mn, 52mMn, and 52gMn, are positron emitters that are potentially interesting for …

Positron emission tomography after ischemic brain injury: current challenges and future developments

Z Wang, C Mascarenhas, X Jia - Translational stroke research, 2020 - Springer
Positron emission tomography (PET) is widely used in clinical and animal studies, along
with the development of diverse tracers. The biochemical characteristics of PET tracers may …