Systemic lupus erythematosus (SLE) is a severe multisystem autoimmune disease that can cause injury in almost every body system. While considered a classic example of …
I Parodis, M Gatto, C Sjöwall - Frontiers in Medicine, 2022 - frontiersin.org
B cell hyperactivity is a hallmark of the complex autoimmune disease systemic lupus erythematosus (SLE), which has justified drug development focusing on B cell altering …
Y Song, J Li, Y Wu - Signal Transduction and Targeted Therapy, 2024 - nature.com
Autoimmune disorders are characterized by aberrant T cell and B cell reactivity to the body's own components, resulting in tissue destruction and organ dysfunction. Autoimmune …
L Arbitman, R Furie, H Vashistha - Journal of Autoimmunity, 2022 - Elsevier
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown etiology that primarily affects women of childbearing age. There is no disease more heterogeneous …
AR Parra Sánchez, RF van Vollenhoven… - Rheumatology and …, 2023 - Springer
Remission is the established therapeutic goal for patients with systemic lupus erythematosus (SLE) and is currently defined by the widely adopted Definition Of Remission …
M Plüß, S Piantoni, B Tampe, AHJ Kim… - Human Vaccines & …, 2022 - Taylor & Francis
In recent years, advances in the treatment and management of patients with systemic lupus erythematosus (SLE) have improved their life expectancy and quality of life. However, lupus …
M Gatto, R Depascale, AL Stefanski… - Best Practice & …, 2023 - Elsevier
Improved characterization of relevant pathogenic pathways in systemic lupus erythematosus (SLE) has been further delineated over the last decades. This led to the development of …
Objective The ability to regulate B cell development has long been recognized to have therapeutic potential in a variety of autoimmune diseases. However, despite the presence of …