The visual/β-arrestins, a small family of proteins originally described for their role in the
desensitization and intracellular trafficking of G protein–coupled receptors (GPCRs), have …

Upon their discovery, β-arrestins 1 and 2 were named for their capacity to sterically hinder
the G protein coupling of agonist-activated seven-transmembrane receptors, ultimately …

Arrestin proteins bind to active, phosphorylated G-protein-coupled receptors (GPCRs),
thereby preventing G-protein coupling, triggering receptor internalization and affecting …

Arrestins interact with G protein–coupled receptors (GPCRs) to stop G protein activation and
to initiate key signaling pathways. Recent structural studies shed light on the molecular …

Arrestins have pivotal roles in regulating G protein-coupled receptor (GPCR) signalling by
desensitizing G protein activation and mediating receptor internalization,. It has been …

Growth factors, such as insulin, can induce both acute and long-term glucose uptake into
cells. Apart from the rapid, insulin-induced fusion of glucose transporter (GLUT) 4 storage …

β-Arrestins, originally discovered to desensitize activated seven transmembrane receptors
(7TMRs; also known as G-protein-coupled receptors, GPCRs), are now well established …

To ensure that extracellular stimuli are translated into intracellular signals of appropriate
magnitude and specificity, most signaling cascades are tightly regulated. One of the major …

The β-arrestins (βarrs) are versatile, multifunctional adapter proteins that are best known for
their ability to desensitize G protein-coupled receptors (GPCRs), but also regulate a diverse …

β-arrestins are cytosolic proteins that form complexes with seven-transmembrane receptors
after agonist stimulation and phosphorylation by the G protein-coupled receptor kinases …