Membranous nephropathy (MN) is a unique glomerular lesion that is the most common
cause of idiopathic nephrotic syndrome in nondiabetic white adults. About 80% of cases are …

The new respiratory infectious disease coronavirus disease 2019 (COVID-19) that
originated in Wuhan, China, in December 2019 and caused by a new strain of zoonotic …

It is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can
directly infect human kidney, thus leading to acute kidney injury (AKI). Here, we perform a …

Primary membranous nephropathy (pMN) is a leading cause of nephrotic syndrome in
adults. In most cases, this autoimmune kidney disease is associated with autoantibodies …

Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries
and that neighbor cells of the Bowman's capsule. When it comes to glomerular filtration …

Age-related macular degeneration (AMD) is a common and devastating disease that can
result in severe visual dysfunction. Over the last decade, great progress has been made in …

The final common pathway of all routes of complement activation involves the non-
enzymatic assembly of a complex comprising newly formed C5b with the plasma proteins …

In patients with membranous nephropathy, alkylating agents (cyclophosphamide or
chlorambucil) alone or in combination with steroids achieve remission of nephrotic …

As recently as 2002, most cases of primary membranous nephropathy (MN), a relatively
common cause of nephrotic syndrome in adults, were considered idiopathic. We now …

The membrane attack complex—also known as C5b-9—is the end-product of the classical,
lectin, and alternative complement pathways. It is thought to play an important role in the …