IDO in the tumor microenvironment: inflammation, counter-regulation, and tolerance
DH Munn, AL Mellor - Trends in immunology, 2016 - cell.com
Indoleamine 2, 3-dioxygenase (IDO) has immunoregulatory roles associated with tryptophan
metabolism. These include counter-regulation (controlling inflammation) and acquired …
metabolism. These include counter-regulation (controlling inflammation) and acquired …
Abnormal kynurenine pathway of tryptophan catabolism in cardiovascular diseases
Kynurenine pathway (KP) is the primary path of tryptophan (Trp) catabolism in most
mammalian cells. The KP generates several bioactive catabolites, such as kynurenine (Kyn) …
mammalian cells. The KP generates several bioactive catabolites, such as kynurenine (Kyn) …
Reversal of indoleamine 2, 3-dioxygenase–mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme
Increased tryptophan (Trp) catabolism in the tumor microenvironment (TME) can mediate
immune suppression by upregulation of interferon (IFN)-γ-inducible indoleamine 2, 3 …
immune suppression by upregulation of interferon (IFN)-γ-inducible indoleamine 2, 3 …
Kynurenine pathway metabolism and immune activation: Peripheral measurements in psychiatric and co-morbid conditions
B Strasser, K Becker, D Fuchs, JM Gostner - Neuropharmacology, 2017 - Elsevier
Immune activation is inextricably linked with dysregulation of the tryptophan metabolism,
shifting catabolic routes towards oxidative breakdown along the kynurenine axis. Several …
shifting catabolic routes towards oxidative breakdown along the kynurenine axis. Several …
[HTML][HTML] Amino acid metabolism as drug target in autoimmune diseases
In mammals, amino acid metabolism has evolved to control immune responses.
Autoimmune diseases are heterogeneous conditions that involve the breakdown of …
Autoimmune diseases are heterogeneous conditions that involve the breakdown of …
Tryptophan-Derived 3-Hydroxyanthranilic Acid Contributes to Angiotensin II–Induced Abdominal Aortic Aneurysm Formation in Mice In Vivo
Background: Abnormal amino acid metabolism is associated with vascular disease.
However, the causative link between dysregulated tryptophan metabolism and abdominal …
However, the causative link between dysregulated tryptophan metabolism and abdominal …
Advances in knowledge of inhibitor formation in severe haemophilia A
M Cormier, P Batty, J Tarrant… - British Journal of …, 2020 - Wiley Online Library
Anti‐drug antibody formation following factor VIII (FVIII) replacement therapy is the most
important treatment‐related complication in patients with severe haemophilia A. A significant …
important treatment‐related complication in patients with severe haemophilia A. A significant …
[HTML][HTML] Molecular mechanisms of inhibitor development in hemophilia
The development of neutralizing antibodies in hemophilia is a serious complication of factor
replacement therapy. These antibodies, also known as “inhibitors”, significantly increase …
replacement therapy. These antibodies, also known as “inhibitors”, significantly increase …
The proatherosclerotic function of indoleamine 2, 3-dioxygenase 1 in the developmental stage of atherosclerosis
H Liang, M Chen, F Qi, L Shi, Z Duan, R Yang… - Signal transduction and …, 2019 - nature.com
Abstract The discrepancy of indoleamine 2, 3-dioxygenase 1 (IDO1) function in
atherosclerosis has been noted. Compared to the protective effect of IDO1 against …
atherosclerosis has been noted. Compared to the protective effect of IDO1 against …
Innovative approaches for immune tolerance to factor VIII in the treatment of hemophilia A
A Sherman, M Biswas, RW Herzog - Frontiers in immunology, 2017 - frontiersin.org
Hemophilia A (coagulation factor VIII deficiency) is a debilitating genetic disorder that is
primarily treated with intravenous replacement therapy. Despite a variety of factor VIII protein …
primarily treated with intravenous replacement therapy. Despite a variety of factor VIII protein …