Mechanistic understanding from molecular dynamics in pharmaceutical research 2: lipid membrane in drug design
We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …
context of the role that the lipid membrane can play in drug action, ie, the interaction …
Unlocking the bacterial membrane as a therapeutic target for next-generation antimicrobial amphiphiles
Gram-positive bacteria like Enterococcus faecium and Staphylococcus aureus, and Gram-
negative bacteria like Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas …
negative bacteria like Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas …
Recent developments in membrane targeting antifungal agents to mitigate antifungal resistance
Fungal infections cause severe and life-threatening complications especially in
immunocompromised individuals. Antifungals targeting cellular machinery and cell …
immunocompromised individuals. Antifungals targeting cellular machinery and cell …
[HTML][HTML] Facial amphiphilicity index correlating chemical structures with antimicrobial efficacy
Facial amphiphilicity is an extraordinary chemical structure feature of a variety of
antimicrobial peptides and polymers. Vast efforts have been dedicated to small molecular …
antimicrobial peptides and polymers. Vast efforts have been dedicated to small molecular …
Recent advances in steroid amino acid conjugates: Old scaffolds with new dimensions
P Singla, DB Salunke - European Journal of Medicinal Chemistry, 2020 - Elsevier
Hybrid chemical compounds formed by conjugation of two or more bioactive molecules have
shown wide variety of applications in biology, microelectronics as well as material sciences …
shown wide variety of applications in biology, microelectronics as well as material sciences …
Recent progress in bile acid-based antimicrobials
C Lin, Y Wang, M Le, KF Chen, YG Jia - Bioconjugate Chemistry, 2021 - ACS Publications
With the emergence of drug-resistant bacteria and the formation of biofilms by bacteria and
fungi, microbial infections gradually threaten global health. Natural antimicrobial peptides …
fungi, microbial infections gradually threaten global health. Natural antimicrobial peptides …
Recent advances in biomedical applications of cholic acid-based macromolecules
In recent decades, polymeric materials have been extensively investigated for their
widespread therapeutic applications in various biomedical fields. In particular, biomolecule …
widespread therapeutic applications in various biomedical fields. In particular, biomolecule …
Macromolecular nanotherapeutics and antibiotic adjuvants to tackle bacterial and fungal infections
The escalating rise in the population of multidrug‐resistant (MDR) pathogens coupled with
their biofilm forming ability has struck the global health as nightmare. Alongwith the threat of …
their biofilm forming ability has struck the global health as nightmare. Alongwith the threat of …
Foliar Application or Seed Priming of Cholic Acid-Glycine Conjugates can Mitigate/Prevent the Rice Bacterial Leaf Blight Disease via Activating Plant Defense Genes
Xanthomonas Oryzae pv. oryzae (Xoo) causes bacterial blight and Rhizoctonia solani (R.
solani) causes sheath blight in rice accounting for> 75% of crop losses. Therefore, there is …
solani) causes sheath blight in rice accounting for> 75% of crop losses. Therefore, there is …
Minimising blood stream infection: developing new materials for intravascular catheters
C Casimero, T Ruddock, C Hegarty, R Barber… - Medicines, 2020 - mdpi.com
Catheter related blood stream infection is an ever present hazard for those patients requiring
venous access and particularly for those requiring long term medication. The …
venous access and particularly for those requiring long term medication. The …