Molecular and functional imaging in cancer-targeted therapy: current applications and future directions

JW Bai, SQ Qiu, GJ Zhang - Signal Transduction and Targeted Therapy, 2023 - nature.com
Targeted anticancer drugs block cancer cell growth by interfering with specific signaling
pathways vital to carcinogenesis and tumor growth rather than harming all rapidly dividing …

Tumour microenvironment responsive nanoconstructs for cancer theranostic

A Gulzar, J Xu, C Wang, F He, D Yang, S Gai, P Yang… - Nano today, 2019 - Elsevier
The tumour mass is made up of not only of a heterogeneous population of cancer cells
nonetheless also a mixture of resident as well as the infiltrating host cells, secreted factors …

Cancer biomarkers: selecting the right drug for the right patient

GJ Kelloff, CC Sigman - Nature reviews Drug discovery, 2012 - nature.com
This Perspective highlights biomarkers that are expressed as a consequence of cancer
development and progression. We focus on those biomarkers that are most relevant for …

Manganese Dioxide Coated WS2@Fe3O4/sSiO2 Nanocomposites for pH‐Responsive MR Imaging and Oxygen‐Elevated Synergetic Therapy

G Yang, R Zhang, C Liang, H Zhao, X Yi, S Shen… - Small, 2018 - Wiley Online Library
Recently, the development of multifunctional theranostic nanoplatforms to realize tumor‐
specific imaging and enhanced cancer therapy via responding or modulating the tumor …

Non–Small Cell Lung Cancer Treated with Erlotinib: Heterogeneity of 18F-FDG Uptake at PET—Association with Treatment Response and Prognosis

GJR Cook, ME O'Brien, M Siddique, S Chicklore… - Radiology, 2015 - pubs.rsna.org
Purpose To determine if first-order and high-order textural features on fluorine 18 (18F)
fluorodeoxyglucose (FDG) positron emission tomography (PET) images of non–small cell …

Reversal of warburg effect and reactivation of oxidative phosphorylation by differential inhibition of EGFR signaling pathways in non–small cell lung cancer

V De Rosa, F Iommelli, M Monti, R Fonti, G Votta… - Clinical Cancer …, 2015 - AACR
Purpose: One of the hallmarks of cancer cells is the excessive conversion of glucose to
lactate under normoxic conditions, also known as the Warburg effect. Here, we tested …

The value of FDG PET/CT in treatment response assessment, follow-up, and surveillance of lung cancer

S Sheikhbahaei, E Mena… - American Journal of …, 2017 - Am Roentgen Ray Soc
OBJECTIVE. The purpose of this article is to summarize the evidence regarding the role of
FDG PET/CT in treatment response assessment and surveillance of lung cancer and to …

[HTML][HTML] A systematic review on [18F] FLT-PET uptake as a measure of treatment response in cancer patients

VR Bollineni, GM Kramer, EP Jansma, Y Liu… - European Journal of …, 2016 - Elsevier
Imaging biomarkers have a potential to depict the hallmarks of cancers that characterise
cancer cells as compared to normal cells. One pertinent example is 3′-deoxy-3′-18 F …

Marked, Homogeneous, and Early [18F]Fluorodeoxyglucose–Positron Emission Tomography Responses to Vemurafenib in BRAF-Mutant Advanced Melanoma

GA McArthur, I Puzanov, R Amaravadi… - Journal of Clinical …, 2012 - ascopubs.org
Purpose Imaging with [18F] fluorodeoxyglucose (FDG)–positron emission tomography (PET)
allows early recognition of a response to agents that target key driver mutations in human …

State of the art: response assessment in lung cancer in the era of genomic medicine

M Nishino, H Hatabu, BE Johnson, TC McLoud - Radiology, 2014 - pubs.rsna.org
Tumor response assessment has been a foundation for advances in cancer therapy. Recent
discoveries of effective targeted therapy for specific genomic abnormalities in lung cancer …