Pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (KGDH) are vital entry
points for monosaccharides and amino acids into the Krebs cycle and thus integral for …

Simple Summary Alterations of the MEK5/ERK5 signaling pathway have been described in
several tumors, and emerging data are trying to explain the complexity of ERK5-related …

Aims Recent studies have revealed a close connection between cellular metabolism and the
chronic inflammatory process of atherosclerosis. While the link between systemic …

Diffuse gliomas are devastating brain tumors. Here, we perform a proteogenomic profiling of
213 retrospectively collected glioma tumors. Proteogenomic analysis reveals the …

Small-cell lung cancer (SCLC) is an aggressive form of lung cancer with dismal survival
rates. While kinases often play key roles driving tumorigenesis, there are strikingly few …

Purpose The immuno-nutritional status is closely related to the prognosis in many cancers.
Controlling nutritional status (CONUT) score is a new parameter that reflects the immuno …

Leukemic cells proliferate faster than non-transformed counterparts. This requires them to
change their metabolism to adapt to their high growth. This change can stress cells and …

Autistic spectrum disease (ASD) is an increasingly common diagnosis nowadays with a
prevalence of 1–2% in most countries. Its complex causality—a combination of genetic …

The mechanical properties of solid tumors influence tumor cell phenotype and the ability to
invade surrounding tissues. Using bioengineered scaffolds to provide a matrix …

In omnivorous fish, the pyruvate dehydrogenase kinases (PDKs)-pyruvate dehydrogenase
E1α subunit (PDHE1α) axis is essential in the regulation of carbohydrate oxidative …