[HTML][HTML] Effects of environmental contaminants in water resources on nonalcoholic fatty liver disease

S Zheng, Y Yang, C Wen, W Liu, L Cao, X Feng… - Environment …, 2021 - Elsevier
The global prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing
rapidly in recent years, which is now estimated to be over 25%. NAFLD is one of the most …

Cyanobacterial Harmful Algal Bloom Toxin Microcystin and Increased Vibrio Occurrence as Climate-Change-Induced Biological Co-Stressors: Exposure and Disease …

S Chatterjee, M More - Toxins, 2023 - mdpi.com
The effects of global warming are not limited to rising global temperatures and have set in
motion a complex chain of events contributing to climate change. A consequence of global …

Altered gut microbiome in a mouse model of Gulf War Illness causes neuroinflammation and intestinal injury via leaky gut and TLR4 activation

F Alhasson, S Das, R Seth, D Dattaroy… - PloS one, 2017 - journals.plos.org
Many of the symptoms of Gulf War Illness (GWI) that include neurological abnormalities,
neuroinflammation, chronic fatigue and gastrointestinal disturbances have been traced to …

Mechanistic and therapeutic role of NLRP3 inflammasome in the pathogenesis of Alzheimer's disease

D Jha, ENTP Bakker, R Kumar - Journal of neurochemistry, 2024 - Wiley Online Library
Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, has emerged
as the most common form of dementia in the elderly. Several pathological hallmarks have …

Disinfection Byproducts of Haloacetaldehydes Disrupt Hepatic Lipid Metabolism and Induce Lipotoxicity in High-Fat Culture Conditions

L Yang, Z Jiang, L Yang, W Zheng… - Environmental …, 2024 - ACS Publications
Unhealthy lifestyles, obesity, and environmental pollutants are strongly correlated with the
development of nonalcoholic fatty liver disease (NAFLD). Haloacetaldehyde-associated …

Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis

D Dattaroy, S Pourhoseini, S Das… - American Journal …, 2015 - journals.physiology.org
Hepatic fibrosis in nonalcoholic steatohepatitis (NASH) is the common pathophysiological
process resulting from chronic liver inflammation and oxidative stress. Although significant …

Evaluation of Aroclor 1260 exposure in a mouse model of diet-induced obesity and non-alcoholic fatty liver disease

B Wahlang, M Song, JI Beier, KC Falkner… - Toxicology and applied …, 2014 - Elsevier
Polychlorinated biphenyls (PCBs) are persistent organic pollutants associated with non-
alcoholic fatty liver disease (NAFLD) in epidemiologic studies. The purpose of this study was …

[HTML][HTML] Alcoholic, nonalcoholic, and toxicant-associated steatohepatitis: mechanistic similarities and differences

S Joshi-Barve, I Kirpich, MC Cave, LS Marsano… - Cellular and molecular …, 2015 - Elsevier
Hepatic steatosis and steatohepatitis are common histologic findings that can be caused by
multiple etiologies. The three most frequent causes for steatosis/steatohepatitis are alcohol …

Prolonged exposure to low-dose microcystin induces nonalcoholic steatohepatitis in mice: a systems toxicology study

J He, G Li, J Chen, J Lin, C Zeng, J Chen, J Deng… - Archives of …, 2017 - Springer
Abstract Microcystin-LR (MCLR), a cyanotoxin widely present in freshwater, has been shown
to have potent acute hepatotoxicity. However, the chronic toxicity of low-dose MCLR remains …

Role of CYP2E1 in mitochondrial dysfunction and hepatic injury by alcohol and non-alcoholic substances

MA Abdelmegeed, SK Ha, Y Choi… - Current molecular …, 2017 - ingentaconnect.com
Alcoholic fatty liver disease (AFLD) and non-alcoholic fatty liver disease (NAFLD) are two
pathological conditions that are spreading worldwide. Both conditions are remarkably …