[HTML][HTML] Twenty years of discoveries emerging from mouse models of autism

JN Crawley - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
More than 100 single gene mutations and copy number variants convey risk for autism
spectrum disorder. To understand the extent to which each mutation contributes to the …

[HTML][HTML] Novel pharmacotherapies in Parkinson's disease

Y Tizabi, B Getachew, M Aschner - Neurotoxicity Research, 2021 - Springer
Abstract Parkinson's disease (PD), an age-related progressive neurodegenerative condition,
is associated with loss of dopaminergic neurons in the substantia nigra pars compacta …

[HTML][HTML] The live biotherapeutic Blautia stercoris MRx0006 attenuates social deficits, repetitive behaviour, and anxiety-like behaviour in a mouse model relevant to …

P Sen, E Sherwin, K Sandhu, TFS Bastiaanssen… - Brain, behavior, and …, 2022 - Elsevier
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by deficits
in social behaviour, increased repetitive behaviour, anxiety and gastrointestinal symptoms …

Metformin Alleviates Autistic‐Like Behaviors Elicited by High‐Fat Diet Consumption and Modulates the Crosstalk Between Serotonin and Gut Microbiota in Mice

W Deng, H Ke, S Wang, Z Li, S Li, P Lv… - Behavioural …, 2022 - Wiley Online Library
The biological mechanisms linking diet‐related obesity and autistic behaviors remain
unclear. Metformin has proven to be beneficial in the treatment of many syndromes …

[HTML][HTML] Kefir ameliorates specific microbiota-gut-brain axis impairments in a mouse model relevant to autism spectrum disorder

M van de Wouw, CJ Walsh, GMD Vigano… - Brain, Behavior, and …, 2021 - Elsevier
Autism spectrum disorder (ASD) is one of the most severe developmental disorders,
affecting on average 1 in 150 children worldwide. There is a great need for more effective …

Questionable research practices, low statistical power, and other obstacles to replicability: Why preclinical neuroscience research would benefit from Registered …

RJ Ellis - eneuro, 2022 - eneuro.org
Replicability, the degree to which a previous scientific finding can be repeated in a distinct
set of data, has been considered an integral component of institutionalized scientific practice …

The microbiome-gut-brain axis in nutritional neuroscience

H Schellekens, G Ribeiro, C Cuesta-Marti… - Nutritional …, 2023 - Taylor & Francis
Emerging evidence is highlighting the microbiome as a key regulator of the effect of nutrition
on gut-brain axis signaling. Nevertheless, it is not yet clear whether the impact of nutrition is …

[HTML][HTML] 5-Aminoisoquinolinone, a PARP-1 inhibitor, ameliorates immune abnormalities through upregulation of anti-inflammatory and downregulation of inflammatory …

K Alhosaini, MA Ansari, A Nadeem, SA Bakheet… - Brain Sciences, 2021 - mdpi.com
Autism spectrum disorder (ASD) covers a range of neurodevelopmental disorders involving
impairments in communication and repetitive and stereotyped patterns of behavior and …

Reversal of electrophysiological and behavioral deficits mediated by 5-HT7 receptor upregulation following LP-211 treatment in an autistic-like rat model induced by …

M Rahdar, S Davoudi, S Dehghan, M Javan… - …, 2024 - Elsevier
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by
alterations and imbalances in multiple brain neurochemical systems, particularly the …

[HTML][HTML] Evaluating the effect of R-Baclofen and LP-211 on autistic behavior of the BTBR and Fmr1-KO mouse models

S Sharghi, S Flunkert, M Daurer, R Rabl… - Frontiers in …, 2023 - frontiersin.org
Introduction Autism spectrum disorder (ASD) is a persistent neurodevelopmental condition
characterized by two core behavioral symptoms: impaired social communication and …