Epigenetic regulation in fibrosis progress

T Xue, X Qiu, H Liu, C Gan, Z Tan, Y Xie, Y Wang… - Pharmacological …, 2021 - Elsevier
Fibrosis, a common process of chronic inflammatory diseases, is defined as a repair
response disorder when organs undergo continuous damage, ultimately leading to scar …

Molecular and tissue alterations of collagens in fibrosis

S Ricard-Blum, G Baffet, N Théret - Matrix Biology, 2018 - Elsevier
The collagen network is altered in fibrotic diseases associated with extracellular matrix
(ECM) biosynthesis and remodeling. This mini-review focuses on the quantitative and …

[HTML][HTML] Epigenetic modification in liver fibrosis: Promising therapeutic direction with significant challenges ahead

R Liu, Y Li, Q Zheng, M Ding, H Zhou, X Li - Acta Pharmaceutica Sinica B, 2024 - Elsevier
Liver fibrosis, characterized by scar tissue formation, can ultimately result in liver failure. It's a
major cause of morbidity and mortality globally, often associated with chronic liver diseases …

[HTML][HTML] Epigenetic reprogramming in liver fibrosis and cancer

CL Wilson, DA Mann, LA Borthwick - Advanced Drug Delivery Reviews, 2017 - Elsevier
Novel insights into the epigenetic control of chronic liver diseases are now emerging.
Recent advances in our understanding of the critical roles of DNA methylation, histone …

Epigenetics in liver fibrosis: could HDACs be a therapeutic target?

A Claveria-Cabello, L Colyn, M Arechederra… - Cells, 2020 - mdpi.com
Chronic liver diseases (CLD) represent a worldwide health problem. While CLDs may have
diverse etiologies, a common pathogenic denominator is the presence of liver fibrosis …

[HTML][HTML] Combinatorial Treatment with Praziquantel and Curcumin Reduces Clonorchis sinensis Parasite Burden and Clonorchiasis-Associated Pathologies in Rats

SO Lee, KB Chu, KW Yoon, SI Heo, JH Song, J Li… - Pharmaceutics, 2024 - mdpi.com
Background/Objectives: Clonorchiasis is a foodborne parasitic disease that can lead to
severe biliary fibrosis and cholangiocarcinoma. While praziquantel (PZQ) is available for …

Inhibitory effects of octreotide on the progression of hepatic fibrosis via the regulation of Bcl-2/Bax and PI3K/AKT signaling pathways

C Zhang, R An, YW Bao, XM Meng, TQ Wang… - International …, 2019 - Elsevier
In a previous study, we showed that octreotide alleviate hepatic fibrosis. However, its
underlying molecular mechanisms are still poorly understood. In the current study, rats with …

Dealing with schistosomiasis: Current drug discovery strategies

S Gemma, S Federico, S Brogi, M Brindisi… - Annual Reports in …, 2019 - Elsevier
Schistosomiasis is one of the most prevalent parasitic diseases, accounting for heavy
socioeconomical and health burden in endemic countries. The control of this neglected …

Anti-fibrotic Effect of Oral Versus Intraperitoneal Administration of Gold Nanoparticles in Hepatic Schistosoma mansoni-Infected Mice

SAA Ahmed, SEM Gad, OM Eida, LM Makhlouf - Acta Parasitologica, 2024 - Springer
Background Schistosomiasis significantly impacts public health, as it causes severe
morbidity. Infections caused by Schistosoma mansoni (S. mansoni) can be treated with gold …

[PDF][PDF] 肝星状细胞活化和肝细胞性肝癌发生发展中的表观遗传学研究进展

安召宏, 钟庆, 徐启云, 刘向前 - CHINESE JOURNAL OF …, 2020 - researchgate.net
肝星状细胞活化与肝纤维化, 肝硬化和肝癌的发生, 发展密切相关; 多种表观遗传学机制参与肝星
状细胞的活化和肝细胞性肝癌的发生, 发展. 本文在DNA 甲基化, 组蛋白修饰, miRNA …