One of the hallmark advances in our understanding of metalloprotein function is showcased
in our ability to design new, non-native, catalytically active protein scaffolds. This review …

Hemes remain one of the most visible and versatile classes of cofactors utilized in biology. 1
Since their discovery, the structural and functional aspects of heme proteins have fascinated …

Conspectus De novo protein design represents an attractive approach for testing and
extending our understanding of metalloprotein structure and function. Here, we describe our …

▪ Abstract De novo protein design has recently emerged as an attractive approach for
studying the structure and function of proteins. This approach critically tests our …

Many efforts are being made in the design and engineering of metalloenzymes with catalytic
properties fulfilling the needs of practical applications. Progress in this field has recently …

De novo protein design has proven to be a powerful tool for understanding protein folding,
structure, and function. In this Account, we highlight aspects of our research on the design of …

De novo protein design provides an attractive approach for the construction of models to
probe the features required for function of complex metalloproteins. The metal-binding sites …

Metalloproteins are involved in fundamental biological processes and utilize a relatively
small number of metal-based prosthetic groups to serve numerous and diverse chemical …

Chiroptical properties of chiral coordination compounds can be used to assign absolute
configuration of ground and excited states. We discuss examples of transition metal …

To define the delicate interplay between metal chelation, protein folding and function in
metalloproteins, a family of de novo-designed peptides was synthesized that self-assemble …