There is a high incidence of chromosomal abnormalities in early human embryos, whether
they are generated by natural conception or by assisted reproductive technologies (ART) …

Retinitis pigmentosa (RP) comprises a group of inherited retinal dystrophies characterized
by the degeneration of rod photoreceptors, followed by the degeneration of cone …

Mammalian fertilization is a fascinating process that leads to the formation of a new
individual. Eggs and sperm are complex cells that must meet at the appropriate time and …

Preimplantation genetic testing (PGT) of in-vitro-fertilized embryos has been proposed as a
method to reduce transmission of common disease; however, more comprehensive embryo …

Recently, 2 branches of the wide area of synthetic biology—in vitro gametogenesis and
synthetic embryo development—have gained considerable attention. Rodent induced …

High-throughput sequencing technologies have increasingly led to discovery of disease-
causing genetic variants, primarily in postnatal multi-cell DNA samples. However, applying …

BACKGROUND Miscarriage describes the spontaneous loss of pregnancy before the
threshold of viability; the vast majority occur before 12 weeks of gestation. Miscarriage …

The process of morphological examination of embryos is one of the most important selection
methods, according to the results of which an assessment is made of a whole group of …

Recent advances in genomic technologies expand the scope and efficiency of
preimplantation genetic testing (PGT). We previously developed Haploseek, a clinically …

Purpose To explore how the assisted reproductive technology (ART) laboratories can be
optimized and standardized to enhance embryo culture and selection, to bridge the gap …