Purpose Cervical cancer (CC), one of the major causes of death of women throughout the
world is primarily caused due to Human Papilloma Virus (HPV) 16 and 18. The early region …

Resistance to therapy is the major hurdle in the current cancer management. Cancer cells
often rewire their cellular process to alternate mechanisms to resist the deleterious effect …

Epithelial–mesenchymal transition (EMT) is an important process during development by
which epithelial cells acquire mesenchymal, fibroblast-like properties and show reduced …

The prognosis of cervical patients significantly decreases as the cancer metastasizes to
other parts of the body. The epithelial to mesenchymal transition (EMT) plays an important …

Abstract Infection with Human papillomaviruses (HPVs) leads to the development of a wide-
range of cancers, accounting for 5% of all human cancers. A prominent example is cervical …

The Notch pathway is increasingly attracting attention as a source of therapeutic targets for
cancer. Ligand-induced Notch signaling has been implicated in various aspects of cancer …

Canonical Notch signaling is initiated by γ-secretase-mediated cleavage of the Notch
receptor, leading to the release of the active intra-cellular domain of Notch that migrates to …

Over the last two decades, since the initial discovery of human papillomavirus (HPV) type 16
and 18 DNAs in cervical cancers by Dr. Harald zur Hausen (winner of the Nobel Prize in …

Purpose: Acquisition of epithelial-mesenchymal transition (EMT) by primary carcinoma cells
is associated with disrupted epithelial integrity, local invasion, and ultimately metastasis …

Hes1 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a
critical role in many physiological processes including cellular differentiation, cell cycle …