Disruption of small molecule transporter systems by Transporter‐Interfering Chemicals (TICs)

SCT Nicklisch, A Hamdoun - FEBS letters, 2020 - Wiley Online Library
Small molecule transporters (SMTs) in the ABC and SLC families are important players in
disposition of diverse endo‐and xenobiotics. Interactions of environmental chemicals with …

A critical review on modulators of Multidrug Resistance Protein 1 in cancer cells

VO Poku, SH Iram - PeerJ, 2022 - peerj.com
Abstract Multidrug resistance protein 1 (MRP1/ABCC1) is an ATP-dependent efflux
transporter, and responsible for the transport of a broad spectrum of xenobiotics, toxins, and …

[HTML][HTML] Doxorubicin as a fluorescent reporter identifies novel MRP1 (ABCC1) inhibitors missed by calcein-based high content screening of anticancer agents

A Sampson, BG Peterson, KW Tan, SH Iram - Biomedicine & …, 2019 - Elsevier
Abstract Multidrug resistance protein 1 (MRP1/ABCC1) actively transports a variety of drugs,
toxic molecules and important physiological substrates across the plasma membrane. It can …

Triazole-estradiol analogs: A potential cancer therapeutic targeting ovarian and colorectal cancer

T Ostlund, F Alotaibi, J Kyeremateng, H Halaweish… - Steroids, 2022 - Elsevier
triazoles have continuously shown effectiveness as biologically active systems towards
various cancers, and when used in combination with steroid skeletons as a carrier, which …

The effect of nanosystems on ATP-binding cassette transporters: understanding the influence of nanosystems on multidrug resistance protein-1 and P-glycoprotein

FVC Mello, GN de Moraes, RC Maia… - International journal of …, 2020 - mdpi.com
The cancer multidrug resistance is involved in the failure of several treatments during cancer
treatment. It is a phenomenon that has been receiving great attention in the last years due to …

ATP-Binding Cassette Transporter of Clinical Significance: Sideroblastic Anemia

JO Ogunbileje, N Harris, T Wynn, R Kashif… - Journal of Personalized …, 2024 - mdpi.com
The ATP-binding cassette (ABC) transporters are a vast group of 48 membrane proteins,
some of which are of notable physiological and clinical importance. Some ABC transporters …

Force in numbers: high-throughput screening approaches to unlock microbial transport

LRJ Sánchez, S Claus, LT Muth, JMS Lopez… - Current Opinion in …, 2022 - Elsevier
Highlights•Transport is a vital research area for developing successful cell factories, yet
challenging to study and engineer.•Coupling transport to growth rates can provide high …

[图书][B] Characterization of Cucurbitacin-Inspired Estrone Analogues as Novel Inhibitors of Human ATP-Binding Cassette Proteins (ABCB1 and ABCC1)

J Kyeremateng - 2021 - search.proquest.com
ATP-binding cassette (ABC) transporters are a large class of integral membrane proteins
that contribute to key physiological functions in all organisms by utilizing ATP binding and …

Specyficzność substratowa, aktywność i lokalizacja subkomórkowa ludzkiego białka oporności wielolekowej ABCG2

M Studzian - 2023 - dspace.uni.lodz.pl
Białko ABCG2 u człowieka funkcjonuje jako transporter wielu substancji o znaczeniu
fizjologicznym–metabolitów, składników pożywienia, leków. Celem niniejszej pracy było …