For more than two decades, sepsis was defined as a microbial infection that produces fever
(or hypothermia), tachycardia, tachypnoea and blood leukocyte changes. Sepsis is now …

Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …

There is an urgent need to identify the cellular and molecular mechanisms responsible for
severe COVID-19 that results in death. We initially performed both untargeted and targeted …

Sepsis is generally viewed as a disease aggravated by an inappropriate immune response
encountered in the afflicted individual. As an important organ system frequently …

Objectives: To determine which multicenter randomized controlled trials in critically ill
patients have shown that the study intervention was associated with a statistically significant …

Human sepsis is thought to be systemic inflammatory response syndrome (SIRS) that is
activated by invasive infection. The multiple organ dysfunction syndrome (MODS) is the …

Snakebite remains a neglected medical problem of the developing world with up to 125,000
deaths each year despite more than a century of calls to improve snakebite prevention and …

Antibacterial properties of secreted phospholipases A2 (PLA2) have emerged gradually.
Group (G) IIA PLA2 is the most potent among mammalian secreted (s) PLA2s against Gram …

Many lung diseases are characterized by neutrophil-dominated inflammation; therefore, an
understanding of neutrophil function is of considerable importance to respiratory physicians …

Objectives: To determine how many multicenter, randomized controlled trials have been
published that assess mortality as a primary outcome in the adult intensive care unit …