The discovery and evolution of antibiotics for humans and animals are among the most
significant milestones of the 20th century. However, antibiotics play a significant role in the …

Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Integrons are flexible gene-exchanging platforms that contain multiple cassettes encoding
accessory genes whose order is shuffled by a specific integrase. Integrons embedded within …

The intensive use of antibiotics results in their continuous release into the environment and
the subsequent widespread occurrence of antibiotic resistant bacteria (ARB), antibiotic …

As the human population increases there is an increasing reliance on aquaculture to supply
a safe, reliable, and economic supply of food. Although food production is essential for a …

Emergence of antimicrobial resistance (AMR) in cultured fishes is one of the major
challenges faced in aquaculture. The high prevalence of bacterial infections in fishes leads …

Urban wastewater treatment plants (UWTPs) are among the main sources of antibiotics'
release into the environment. The occurrence of antibiotics may promote the selection of …

Antibiotic resistance is rapidly spreading via the horizontal transfer of resistance genes in
mobile genetic elements. While plasmids are key drivers of this process, few integrative …

Integrons are versatile gene acquisition systems commonly found in bacterial genomes.
They are ancient elements that are a hot spot for genomic complexity, generating phenotypic …

Soil microbiota represent one of the ancient evolutionary origins of antibiotic resistance and
have been proposed as a reservoir of resistance genes available for exchange with clinical …