[HTML][HTML] Stem cell systems and regeneration in planaria

JC Rink - Development genes and evolution, 2013 - Springer
Planarians are members of the Platyhelminthes (flatworms). These animals have evolved a
remarkable stem cell system. A single pluripotent adult stem cell type (“neoblast”) gives rise …

Model systems for regeneration: planarians

M Ivankovic, R Haneckova, A Thommen… - …, 2019 - journals.biologists.com
Planarians are a group of flatworms. Some planarian species have remarkable regenerative
abilities, which involve abundant pluripotent adult stem cells. This makes these worms a …

[HTML][HTML] Single-cell analysis reveals functionally distinct classes within the planarian stem cell compartment

JC Van Wolfswinkel, DE Wagner, PW Reddien - Cell stem cell, 2014 - cell.com
Planarians are flatworms capable of regenerating any missing body region. This capacity is
mediated by neoblasts, a proliferative cell population that contains pluripotent stem cells …

[HTML][HTML] A comparative analysis of planarian genomes reveals regulatory conservation in the face of rapid structural divergence

M Ivanković, JN Brand, L Pandolfini, T Brown… - Nature …, 2024 - nature.com
The planarian Schmidtea mediterranea is being studied as a model species for
regeneration, but the assembly of planarian genomes remains challenging. Here, we report …

[HTML][HTML] The Fasciola hepatica genome: gene duplication and polymorphism reveals adaptation to the host environment and the capacity for rapid evolution

K Cwiklinski, JP Dalton, PJ Dufresne, J La Course… - Genome biology, 2015 - Springer
Abstract Background The liver fluke Fasciola hepatica is a major pathogen of livestock
worldwide, causing huge economic losses to agriculture, as well as 2.4 million human …

A comparative transcriptomic analysis reveals conserved features of stem cell pluripotency in planarians and mammals

RM Labbé, M Irimia, KW Currie, A Lin, SJ Zhu… - Stem …, 2012 - academic.oup.com
Many long‐lived species of animals require the function of adult stem cells throughout their
lives. However, the transcriptomes of stem cells in invertebrates and vertebrates have not …

The history and enduring contributions of planarians to the study of animal regeneration

SA Elliott, A Sánchez Alvarado - Wiley Interdisciplinary Reviews …, 2013 - Wiley Online Library
Having an almost unlimited capacity to regenerate tissues lost to age and injury, planarians
have long fascinated naturalists. In the Western hemisphere alone, their documented history …

[HTML][HTML] The genome of the crustacean Parhyale hawaiensis, a model for animal development, regeneration, immunity and lignocellulose digestion

D Kao, AG Lai, E Stamataki, S Rosic, N Konstantinides… - elife, 2016 - elifesciences.org
The amphipod crustacean Parhyale hawaiensis is a blossoming model system for studies of
developmental mechanisms and more recently regeneration. We have sequenced the …

Re-membering the body: applications of computational neuroscience to the top-down control of regeneration of limbs and other complex organs

G Pezzulo, M Levin - Integrative Biology, 2015 - academic.oup.com
A major goal of regenerative medicine and bioengineering is the regeneration of complex
organs, such as limbs, and the capability to create artificial constructs (so-called biobots) …

Gene expression of pluripotency determinants is conserved between mammalian and planarian stem cells

P Önal, D Grün, C Adamidi, A Rybak, J Solana… - The EMBO …, 2012 - embopress.org
Freshwater planaria possess extreme regeneration capabilities mediated by abundant,
pluripotent stem cells (neoblasts) in adult animals. Although planaria emerged as an …