Role of the insulin-like growth factor family in cancer development and progression
The insulin-like growth factors (IGFs) are mitogens that play a pivotal role in regulating cell
proliferation, differentiation, and apoptosis. The effects of IGFs are mediated through the IGF …
proliferation, differentiation, and apoptosis. The effects of IGFs are mediated through the IGF …
Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors
CE Stewart, P Rotwein - Physiological reviews, 1996 - journals.physiology.org
The insulin-like growth factors (IGFs), IGF-I and IGF-II, comprise a conserved pair of secreted
proteins with diverse effects on growth, development, and metabolism. Insulin-like growth …
proteins with diverse effects on growth, development, and metabolism. Insulin-like growth …
Review Insulin-Like Growth Factors I and II
RE Humbel - EJB Reviews 1990, 1990 - Springer
Insulin-like growth factors (IGF) I and II are two peptides which have been isolated originally
from a Cohn fraction of human serum [1]. The designation IGF has been proposed [2] to …
from a Cohn fraction of human serum [1]. The designation IGF has been proposed [2] to …
Relaxation of imprinted genes in human cancer
S Rainier, LA Johnson, CJ Dobry, AJ Ping, PE Grundy… - Nature, 1993 - nature.com
GENOMIC imprinting, or parental allele-specific expression of genes, has been
demonstrated at the molecular level in insects and mice1, 2 but not in man. Imprinting as a …
demonstrated at the molecular level in insects and mice1, 2 but not in man. Imprinting as a …
Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour
O Ogawa, MR Eccles, J Szeto, LA McNoe, K Yun… - Nature, 1993 - nature.com
GENOMIC imprinting has been implicated in the onset of several embryonal tumours but the
mechanism is not well understood1–3. Maternal chromosome 11p15 loss of heterozygosity4 …
mechanism is not well understood1–3. Maternal chromosome 11p15 loss of heterozygosity4 …
Parental genomic imprinting of the human IGF2 gene
The mouse igf2 gene, coding for the insulin–like growth factor II (IGF–II) is parentally
imprinted, only the gene copy derived from the father is expressed. To know whether IGF2 …
imprinted, only the gene copy derived from the father is expressed. To know whether IGF2 …
Yeast MIG1 repressor is related to the mammalian early growth response and Wilms' tumour finger proteins.
JO Nehlin, H Ronne - The EMBO journal, 1990 - embopress.org
We have cloned a yeast gene, MIG1, which encodes a C2H2 zinc finger protein involved in
glucose repression. The fingers of MIG1 are very similar to those present in the mammalian …
glucose repression. The fingers of MIG1 are very similar to those present in the mammalian …
The IGF system
M Annunziata, R Granata, E Ghigo - Acta diabetologica, 2011 - Springer
The insulin-like growth factor (IGF) system plays essential role in the regulation of cell
growth, proliferation and survival and affects nearly every organ system in the body. IGF-I …
growth, proliferation and survival and affects nearly every organ system in the body. IGF-I …
Insulin-like growth factors and cancer.
VM Macaulay - British journal of cancer, 1992 - ncbi.nlm.nih.gov
The insulin-like growth factors (IGFs). also known as somatomedins, have been identified as
a result of three separate lines of research carried out over the last 30 years (Van Wyk & …
a result of three separate lines of research carried out over the last 30 years (Van Wyk & …
[PDF][PDF] Genetics of human cancer
AG Knudson - Annual review of genetics, 1986 - genepi.qimr.edu.au
A large body of evidence amassed from the study of the mechanisms of action of chemical
carcinogens and radiation, and of chromosomal aberrations in cancer cells, supports the …
carcinogens and radiation, and of chromosomal aberrations in cancer cells, supports the …