Gating of voltage-dependent cation channels involves three general molecular processes:
voltage sensor activation, sensor-pore coupling, and pore opening. KCNQ1 is a voltage …

Cardiac action potentials are characterized by an initial depolarization followed by a
prolonged depolarization, or plateau phase, before a return to the resting potential. In these …

The single-span membrane protein KCNE3 modulates a variety of voltage-gated ion
channels in diverse biological contexts. In epithelial cells, KCNE3 regulates the function of …

KCNE b subunits assemble with and modulate the properties of voltagegated K+ channels.
In the heart, KCNE1 associates with KCNQ1 to generate the slowly activating, voltage …

Voltage-activated K+ (KV) channels are important for shaping action potentials and
maintaining resting membrane potential in excitable cells. KV channels contain a central …

The function of the voltage-gated KCNQ1 potassium channel is regulated by co-assembly
with KCNE auxiliary subunits. KCNQ1-KCNE1 channels generate the slow delayed rectifier …

In voltage-gated K+ channels, membrane depolarization induces an upward movement of
the voltage-sensing domains (VSD) that triggers pore opening. KCNQ1 is a voltage-gated …

KCNQ1 is a pore-forming K+ channel subunit critically important to cardiac repolarization at
high heart rates.(2R)-N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl) sulfonyl]-2 …

The gating of the KCNQ1 potassium channel is drastically regulated by auxiliary subunit
KCNE proteins. KCNE1, for example, slows the activation kinetics of KCNQ1 by two orders …

The classical tango is a dance characterized by a 2/4 or 4/4 rhythm in which the partners
dance in a coordinated way, allowing dynamic contact. There is a surprising similarity …