Cystathionine-β-synthase: molecular regulation and pharmacological inhibition

K Zuhra, F Augsburger, T Majtan, C Szabo - Biomolecules, 2020 - mdpi.com
Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration
pathway, is an important mammalian enzyme in health and disease. Its biochemical …

Role of VEGFs/VEGFR-1 signaling and its inhibition in modulating tumor invasion: experimental evidence in different metastatic cancer models

C Ceci, MG Atzori, PM Lacal, G Graziani - International journal of …, 2020 - mdpi.com
The vascular endothelial growth factor (VEGF) family members, VEGF-A, placenta growth
factor (PlGF), and to a lesser extent VEGF-B, play an essential role in tumor-associated …

Direct proteomic mapping of cysteine persulfidation

L Fu, K Liu, J He, C Tian, X Yu, J Yang - Antioxidants & redox …, 2020 - liebertpub.com
Aims: Cysteine persulfidation (also called sulfhydration or sulfuration) has emerged as a
potential redox mechanism to regulate protein functions and diverse biological processes in …

Role of hydrogen sulphide in physiological and pathological angiogenesis

YX Zhang, MR Jing, CB Cai, SG Zhu… - Cell …, 2023 - Wiley Online Library
The role of hydrogen sulphide (H2S) in angiogenesis has been widely demonstrated.
Vascular endothelial growth factor (VEGF) plays an important role in H2S‐induced …

Estrogen receptors and estrogen-induced uterine vasodilation in pregnancy

J Bai, QR Qi, Y Li, R Day, J Makhoul… - International journal of …, 2020 - mdpi.com
Normal pregnancy is associated with dramatic increases in uterine blood flow to facilitate the
bidirectional maternal–fetal exchanges of respiratory gases and to provide sole nutrient …

Mapping pregnancy-dependent Sulfhydrome unfolds diverse functions of protein Sulfhydration in human uterine artery

J Bai, F Jiao, AG Salmeron, S Xu, M Xian… - …, 2023 - academic.oup.com
Uterine artery (UA) hydrogen sulfide (H2S) production is augmented in pregnancy and, on
stimulation by systemic/local vasodilators, contributes to pregnancy-dependent uterine …

Hydrogen sulfide and its role in female reproduction

A Pilsova, Z Pilsova, B Klusackova… - Frontiers in Veterinary …, 2024 - frontiersin.org
Hydrogen sulfide (H2S) is a gaseous signaling molecule produced in the body by three
enzymes: cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and 3 …

[HTML][HTML] Hydrogen sulfide: a versatile molecule and therapeutic target in Health and diseases

A Shahid, M Bhatia - Biomolecules, 2024 - mdpi.com
In recent years, research has unveiled the significant role of hydrogen sulfide (H2S) in many
physiological and pathological processes. The role of endogenous H2S, H2S donors, and …

Cystathionine‑γ‑lyase promotes the metastasis of breast cancer via the VEGF signaling pathway

L Wang, H Shi, Y Liu, W Zhang… - International …, 2019 - spandidos-publications.com
The present study aimed to provide data to support the association between cystathionine‑γ‑
lyase (CSE) and breast cancer metastasis. Reverse transcription‑quantitative polymerase …

Enhanced Stromal Cell CBS-H2S Production Promotes Estrogen-Stimulated Human Endometrial Angiogenesis

QR Qi, TJ Lechuga, B Patel, NA Nguyen… - …, 2020 - academic.oup.com
Angiogenesis is a physiological process for endometrial regeneration in the menstrual cycle
and remodeling during pregnancy. Endogenous hydrogen sulfide (H2S), produced by …