Absorption, distribution, metabolism and excretion (ADME) studies represent a fundamental
step in the early stages of drug discovery. In particular, the absorption of orally administered …

Multidrug resistance (MDR) is a serious problem that hampers the success of cancer
pharmacotherapy. A common mechanism is the overexpression of ATP-binding cassette …

Active drug efflux transporters of the ATP binding cassette (ABC)-containing family of
proteins have a major impact on the pharmacological behavior of most of the drugs in use …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

Observations of functional adenosine triphosphate (ATP)-dependent drug efflux in certain
multidrug-resistant cancer cell lines without overexpression of P-glycoprotein or multidrug …

Abstract The amphetamine derivative (±)-3, 4-methylenedioxymethamphetamine (MDMA,
ecstasy) is a popular recreational drug among young people, particularly those involved in …

The importance of drug transporters as one of the determinants of pharmacokinetics has
become increasingly evident [1]. While much research has been conducted focusing the role …

ATP Binding Cassette (ABC) transporters form a special family of membrane proteins,
characterized by homologous ATP-binding, and large, multispanning transmembrane …

Many orally administered drugs must overcome several barriers before reaching their target
site. The first major obstacle to cross is the intestinal epithelium. Although lipophilic …

Introduction: Drug transporters play an important role in the absorption, distribution, and
excretion (ADE) of many drugs. In the last several years it has become increasingly clear …