Among the central goals of stress neurobiology research is to understand the mechanisms
by which stressors change neural circuit function to precipitate or exacerbate psychiatric …

Benzodiazepine, a classical medication utilized in the treatment of insomnia, operates by
augmenting the activity of the GABA A receptor. This underscores the significance of …

The prefrontal cortex (PFC) enables mammals to respond to situations, including internal
states, with appropriate actions. One such internal state could be 'tiredness'. Here, using …

Sleep is ubiquitous and essential, but its mechanisms remain unclear. Studies in animals
and humans have provided insights of sleep at vastly different spatiotemporal scales …

The brain and gut are intricately connected and respond to various stimuli. Stress-induced
brain-gut communication is implicated in the pathogenesis and relapse of gut disorders. The …

Learned associations between environmental cues and the outcomes they predict (cue-
outcome associations) play a major role in behavioral control, guiding not only which …

Sleep is a vital and evolutionarily conserved process, critical to daily functioning and
homeostatic balance. Losing sleep is inherently stressful and leads to numerous detrimental …

Light in the environment greatly impacts a variety of brain functions, including sleep. Clinical
evidence suggests that bright light treatment has a beneficial effect on stress–related …

Depression is a common chronic psychiatric illness, which is resistant to medical treatments.
While melatonin may alleviate certain depression symptoms, evidence for its efficacy against …

The mechanism of general anesthesia remains elusive. The ventrolateral periaqueductal
gray (vlPAG) in the midbrain regulates sleep and awake states. However, the role of vlPAG …