Idiopathic pulmonary fibrosis: state of the art for 2023

AJ Podolanczuk, CC Thomson… - European …, 2023 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease characterised by
worsening respiratory symptoms and physiological impairment. Increasing awareness of the …

Precision medicine advances in idiopathic pulmonary fibrosis

T Karampitsakos, BM Juan-Guardela, A Tzouvelekis… - …, 2023 - thelancet.com
Idiopathic pulmonary fibrosis (IPF) is a highly heterogeneous, unpredictable and ultimately
lethal chronic lung disease. Over the last decade, two anti-fibrotic agents have been shown …

Treatment of fibrotic interstitial lung disease: current approaches and future directions

KA Johannson, N Chaudhuri, A Adegunsoye… - The Lancet, 2021 - thelancet.com
Fibrotic interstitial lung disease (ILD) represents a large group of pulmonary disorders that
are often progressive and associated with high morbidity and early mortality. Important …

Expression of PD-1/PD-L1 axis in mediastinal lymph nodes and lung tissue of human and experimental lung fibrosis indicates a potential therapeutic target for …

T Karampitsakos, A Galaris, S Chrysikos… - Respiratory …, 2023 - Springer
Background Mediastinal lymph node enlargement is prevalent in patients with idiopathic
pulmonary fibrosis (IPF). Studies investigating whether this phenomenon reflects specific …

Peripheral blood monocyte count and outcomes in patients with interstitial lung disease: a systematic review and meta-analysis

B Min, A Grant-Orser… - European Respiratory …, 2023 - Eur Respiratory Soc
Background Peripheral blood monocyte counts have been associated with poor outcomes in
interstitial lung disease (ILD). However, studies are limited by variable biomarker thresholds …

Challenges for clinical drug development in pulmonary fibrosis

ES White, M Thomas, S Stowasser… - Frontiers in …, 2022 - frontiersin.org
Pulmonary fibrosis is a pathologic process associated with scarring of the lung interstitium.
Interstitial lung diseases (ILDs) encompass a large and heterogenous group of disorders, a …

Lung cancer in patients with idiopathic pulmonary fibrosis: a retrospective multicentre study in Europe

T Karampitsakos, P Spagnolo, N Mogulkoc… - …, 2023 - Wiley Online Library
Abstract Background and Objective There remains a paucity of large databases for patients
with idiopathic pulmonary fibrosis (IPF) and lung cancer. We aimed to create a European …

Genetics and genomics of pulmonary fibrosis: charting the molecular landscape and shaping precision medicine

A Adegunsoye, JA Kropski, J Behr… - American Journal of …, 2024 - atsjournals.org
Recent genetic and genomic advancements have elucidated the complex etiology of
idiopathic pulmonary fibrosis (IPF) and other progressive fibrotic interstitial lung diseases …

Monocytes and macrophages: emerging mechanisms and novel therapeutic targets in pulmonary fibrosis

CY Perrot, T Karampitsakos… - American Journal of …, 2023 - journals.physiology.org
Pulmonary fibrosis results from a plethora of abnormal pathogenetic events. In idiopathic
pulmonary fibrosis (IPF), inhalational, environmental, or occupational exposures in …

Long COVID-19 pulmonary sequelae and management considerations

AK Boutou, A Asimakos, E Kortianou… - Journal of personalized …, 2021 - mdpi.com
The human coronavirus 2019 disease (COVID-19) and the associated acute respiratory
distress syndrome (ARDS) are responsible for the worst global health crisis of the last …