Glycine metabolism and its alterations in obesity and metabolic diseases

A Alves, A Bassot, AL Bulteau, L Pirola, B Morio - Nutrients, 2019 - mdpi.com
Glycine is the proteinogenic amino-acid of lowest molecular weight, harboring a hydrogen
atom as a side-chain. In addition to being a building-block for proteins, glycine is also …

Metabolism and detoxification of pesticides in plants

JJ Zhang, H Yang - Science of the Total Environment, 2021 - Elsevier
Pesticides make indispensable contributions to agricultural productivity. However, the
residues after their excessive use may be harmful to crop production, food safety and human …

Metabolites as risk factors for diabetic retinopathy in patients with type 2 diabetes: a 12-year follow-up study

L Fernandes Silva, J Hokkanen… - The Journal of …, 2024 - academic.oup.com
Context Diabetic retinopathy (DR) is a specific microvascular complication in patients with
diabetes and the leading cause of blindness. Recent advances in omics, especially …

Comparative single-cell analyses identify shared and divergent features of human and mouse kidney development

S Kim, K Koppitch, RK Parvez, J Guo, MA Achieng… - Developmental Cell, 2024 - cell.com
The mammalian kidney maintains fluid homeostasis through diverse epithelial cell types
generated from nephron and ureteric progenitor cells. To extend a developmental …

Creatine maintains intestinal homeostasis and protects against colitis

E Turer, W McAlpine, K Wang, T Lu… - Proceedings of the …, 2017 - National Acad Sciences
Creatine, a nitrogenous organic acid, replenishes cytoplasmic ATP at the expense of
mitochondrial ATP via the phosphocreatine shuttle. Creatine levels are maintained by diet …

Pharmacokinetics of aspirin: evaluating shortcomings in the literature

JL Visagie, GS Aruwajoye… - Expert Opinion on Drug …, 2024 - Taylor & Francis
Introduction Aspirin is known for its therapeutic benefits in preventing strokes and relieving
pain. However, it is toxic to some individuals, and the biological mechanisms causing toxicity …

Derivatization of N-acyl glycines by 3-nitrophenylhydrazine for targeted metabolomics analysis and their application to the study of diabetes progression in mice

L Xiang, Y Ru, J Shi, L Wang, H Zhao… - Analytical …, 2023 - ACS Publications
N-Acyl glycines (NAGlys) are an important class of metabolites in the detoxification system of
the human body. They have been used in the diagnosis of several metabolic diseases …

Identification of ten core hub genes as potential biomarkers and treatment target for hepatoblastoma

R Sun, S Li, K Zhao, M Diao, L Li - Frontiers in oncology, 2021 - frontiersin.org
Background This study aimed to systematically investigate gene signatures for
hepatoblastoma (HB) and identify potential biomarkers for its diagnosis and treatment …

Decreased Expression of GLYATL1 Predicts Poor Prognosis in Patients with Clear Cell Renal Cell Carcinoma

L Deng, H Jiang - International Journal of General Medicine, 2023 - Taylor & Francis
Background GLYATL1 is a member of the glycine-N-acyltransferase family, which catalyses
acyl group transfer. The role of GLYATL1 in cancer is largely unknown; therefore, the …

Characterization of glycine‐N‐acyltransferase like 1 (GLYATL1) in prostate cancer

ML Eich, DS Chandrashekar… - The …, 2019 - Wiley Online Library
Background Recent microarray and sequencing studies of prostate cancer showed multiple
molecular alterations during cancer progression. It is critical to evaluate these molecular …