Recent advances in our understanding of the mechanisms of lung alveolarization and bronchopulmonary dysplasia

E Lignelli, F Palumbo, D Myti… - American Journal of …, 2019 - journals.physiology.org
Bronchopulmonary dysplasia (BPD) is the most common cause of morbidity and mortality in
preterm infants. A key histopathological feature of BPD is stunted late lung development …

Recent advances in the pathogenesis of BPD

RE Morty - Seminars in perinatology, 2018 - Elsevier
Bronchopulmonary dysplasia (BPD) continues to be one of the most common complications
of preterm birth and is characterized histopathologically by impaired lung alveolarization …

STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury

AJ Paris, KE Hayer, JH Oved, DC Avgousti… - Nature Cell …, 2020 - nature.com
Alveolar epithelial regeneration is essential for recovery from devastating lung diseases.
This process occurs when type II alveolar pneumocytes (AT2 cells) proliferate and …

Extracellular vesicles protect the neonatal lung from hyperoxic injury through the epigenetic and transcriptomic reprogramming of myeloid cells

GR Willis, M Reis, AH Gheinani… - American Journal of …, 2021 - atsjournals.org
Rationale: Mesenchymal stem/stromal cell (MSC)–small extracellular vesicle (MEx)
treatment has shown promise in experimental models of neonatal lung injury. The molecular …

Mesenchymal stromal cell-derived small extracellular vesicles restore lung architecture and improve exercise capacity in a model of neonatal hyperoxia-induced lung …

GR Willis, A Fernandez-Gonzalez, M Reis… - Journal of …, 2020 - Taylor & Francis
Early administration of mesenchymal stromal cell (MSC)-derived small extracellular vesicles
(MEx) has shown considerable promise in experimental models of bronchopulmonary …

Preventing bronchopulmonary dysplasia: new tools for an old challenge

M Álvarez-Fuente, L Moreno, JA Mitchell, IK Reiss… - Pediatric …, 2019 - nature.com
Bronchopulmonary dysplasia (BPD) is the most prevalent chronic lung disease in infants
and presents as a consequence of preterm birth. Due to the lack of effective preventive and …

Corneal endothelium tissue engineering: An evolution of signaling molecules, cells, and scaffolds toward 3D bioprinting and cell sheets

M Khalili, M Asadi, H Kahroba… - Journal of Cellular …, 2021 - Wiley Online Library
Cornea is an avascular and transparent tissue that focuses light on retina. Cornea is
supported by the corneal‐endothelial layer through regulation of hydration homeostasis …

The potential therapeutic effect of human umbilical cord mesenchymal stem cell-derived exosomes in bronchopulmonary dysplasia

T Cheng, M Mao, Y Liu, L Xie, F Shi, H Liu, X Li - Life Sciences, 2024 - Elsevier
Bronchopulmonary dysplasia (BPD) is a chronic lung disease of preterm infants, with its
incidence rising due to improved survival rates of these infants. BPD results from a …

Neonatal and fetal therapy of congenital diaphragmatic hernia-related pulmonary hypertension

FR De Bie, CM Avitabile, L Joyeux, HL Hedrick… - Archives of Disease in …, 2022 - fn.bmj.com
Congenital diaphragmatic hernia (CDH) is a complex malformation characterised by a triad
of pulmonary hypoplasia, pulmonary hypertension (PH) and cardiac ventricular dysfunction …

Nanoscaled and microscaled parallel topography promotes tenogenic differentiation of ASC and neotendon formation in vitro

K Zhou, B Feng, W Wang, Y Jiang… - International journal …, 2018 - Taylor & Francis
Background Topography at different scales plays an important role in directing
mesenchymal stem cell differentiation including adipose-derived stem cells (ASCs) and the …