High-throughput and single-cell T cell receptor sequencing technologies
JA Pai, AT Satpathy - Nature methods, 2021 - nature.com
T cells express T cell receptors (TCRs) composed of somatically recombined TCRα and
TCRβ chains, which mediate recognition of major histocompatibility complex (MHC)–antigen …
TCRβ chains, which mediate recognition of major histocompatibility complex (MHC)–antigen …
Single-cell analysis tools for drug discovery and development
The genetic, functional or compositional heterogeneity of healthy and diseased tissues
presents major challenges in drug discovery and development. Such heterogeneity hinders …
presents major challenges in drug discovery and development. Such heterogeneity hinders …
Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery
M Ito, K Komai, S Mise-Omata, M Iizuka-Koga… - Nature, 2019 - nature.com
In addition to maintaining immune tolerance, FOXP3+ regulatory T (Treg) cells perform
specialized functions in tissue homeostasis and remodelling,. However, the characteristics …
specialized functions in tissue homeostasis and remodelling,. However, the characteristics …
Quantifiable predictive features define epitope-specific T cell receptor repertoires
T cells are defined by a heterodimeric surface receptor, the T cell receptor (TCR), that
mediates recognition of pathogen-associated epitopes through interactions with peptide and …
mediates recognition of pathogen-associated epitopes through interactions with peptide and …
Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis
Intestinal adaptive immune responses influence host health, yet only a few intestinal
bacteria species that induce cognate adaptive immune responses during homeostasis have …
bacteria species that induce cognate adaptive immune responses during homeostasis have …
c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont
Both microbial and host genetic factors contribute to the pathogenesis of autoimmune
diseases,,,. There is accumulating evidence that microbial species that potentiate chronic …
diseases,,,. There is accumulating evidence that microbial species that potentiate chronic …
Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury
INTRODUCTION Barrier tissues are constitutive targets of environmental stressors and are
home to a highly diverse microbiota. When the immune system encounters these …
home to a highly diverse microbiota. When the immune system encounters these …
Lymphatic endothelial transcription factor Tbx1 promotes an immunosuppressive microenvironment to facilitate post-myocardial infarction repair
W Wang, X Li, X Ding, S Xiong, Z Hu, X Lu, K Zhang… - Immunity, 2023 - cell.com
The heart is an autoimmune-prone organ. It is crucial for the heart to keep injury-induced
autoimmunity in check to avoid autoimmune-mediated inflammatory disease. However, little …
autoimmunity in check to avoid autoimmune-mediated inflammatory disease. However, little …
Expression of Foxp3 by T follicular helper cells in end-stage germinal centers
JT Jacobsen, W Hu, TB R. Castro, S Solem, A Galante… - Science, 2021 - science.org
INTRODUCTION To produce antibodies that protect effectively against pathogens, B cells
must undergo a Darwinian process of somatic hypermutation of their immunoglobulin genes …
must undergo a Darwinian process of somatic hypermutation of their immunoglobulin genes …
[HTML][HTML] De novo epigenetic programs inhibit PD-1 blockade-mediated T cell rejuvenation
Summary Immune-checkpoint-blockade (ICB)-mediated rejuvenation of exhausted T cells
has emerged as a promising approach for treating various cancers and chronic infections …
has emerged as a promising approach for treating various cancers and chronic infections …