There is a nonlinear relationship between structure and functional processes and the mass
of living organisms. Allometric scaling of body mass provides a theory based method for …

Optimising the dosing of medicines for neonates and children remains a challenge. The
importance of pharmacokinetic (PK) and pharmacodynamic (PD) research is recognised …

Abstract Background and Objectives Uncertainty exists regarding the optimal dosing
regimen for vancomycin in different patient populations, leading to a plethora of subgroup …

Pharmacokinetic/pharmacodynamic (PKPD) modeling is important in the design and
conduct of clinical pharmacology research in children. During drug development, PKPD …

Voriconazole, a second-generation triazole frequently used for the prophylaxis and
treatment of invasive fungal infections, undergoes complex metabolism mainly involving …

Background Fludarabine is often used as an important drug in reduced toxicity conditioning
regimens prior to hematopoietic cell transplantation (HCT). As no definitive pharmacokinetic …

A knowledge gap exists in infant tetrahydrocannabinol (THC) data to guide breastfeeding
recommendations for mothers who use cannabis. In the present study, a paired lactation and …

Background Sepsis and bacterial meningitis are major causes of mortality and morbidity in
neonates and infants. Meropenem, a broad-spectrum antibiotic, is not licensed for use in …

The current demand for pharmacometricians outmatches the supply provided by academic
institutions and considerable investments are made to develop the competencies of these …

Long-term use of imatinib is effective and well-tolerated in children with chronic myeloid
leukaemia (CML) yet defining an optimal dosing regimen for imatinib in younger patients is a …