Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

Opioid use disorder (OUD) is a chronic, relapsing condition, often associated with legal,
interpersonal, and employment problems. Medications demonstrated to be effective for OUD …

Importance Although clinical trials demonstrate the superior effectiveness of medication for
opioid use disorder (MOUD) compared with nonpharmacologic treatment, national data on …

Importance Treatment with methadone or buprenorphine is the current standard of care for
opioid use disorder. Given the paucity of research identifying which patients will respond …

Background Extended-release naltrexone (XR-NTX), an opioid antagonist, and sublingual
buprenorphine-naloxone (BUP-NX), a partial opioid agonist, are pharmacologically and …

Importance Buprenorphine treatment for opioid use disorder may be improved by sustained-
release formulations. Objective To determine whether treatment involving novel weekly and …

Background Opioid dependence is associated with substantial health and social burdens,
and opioid agonist treatment (OAT) is highly effective in improving multiple outcomes for …

Background Guidelines recommend long-term treatment for opioid use disorder with
buprenorphine; however, little is known about patients in long-term treatment. The aim of this …

Opioid use disorder affects over 26 million individuals worldwide. There are currently three
World Health Organization-recommended and US Food and Drug Administration-approved …

Objective: Although counseling is a required part of office-based buprenorphine treatment of
opioid use disorders, the nature of what constitutes appropriate counseling is unclear and …