The heat shock proteins (HSPs) are ubiquitous and conserved protein families in both
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …

Inflammation is central to pathogenic processes in diabetes mellitus and the metabolic
syndrome and particularly implicates innate immunity in the development of complications …

Adoptive cell therapies (ACTs) have existed for decades. From the initial infusion of tumor-
infiltrating lymphocytes to the subsequent specific enhanced T cell receptor (TCR)-T and …

Do long noncoding RNAs (lncRNAs) contribute little or substantively to human biology? To
address how lncRNA loci and their transcripts, structures, interactions, and functions …

Omics-based technologies have revolutionized our understanding of the coding potential of
the genome. In particular, these studies revealed widespread unannotated open reading …

Research showing that microRNAs (miRNAs) are versatile regulators of gene expression
has instigated tremendous interest in cardiovascular research. The overwhelming majority of …

Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides but lacking
canonical coding sequences. Apparently unable to produce peptides, lncRNA function …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mRNA
vaccination induce robust CD4+ T cell responses. Using single-cell transcriptomics, here …

Recent studies have suggested that the initiation and progression of hepatocellular
carcinoma (HCC) are closely associated with lipopolysaccharide (LPS) of intestinal bacteria …

Short ORFs (sORFs), that is, occurrences of a start and stop codon within 100 codons or
less, can be found in organisms of all domains of life, outnumbering annotated protein …