Aurora kinases are a family of serine/threonine kinases that play a crucial role in cell
proliferation through the regulation of mitotic spindles. These kinases are the regulatory …

Introduction: Mammalian cells contain three distinct serine/threonine protein kinases with
highly conserved catalytic domains, including aurora A and B kinases that are essential …

Background The modification and regulation of N6-methyladenosine (m 6 A) at mRNA level
can affect the development and progression in various tumors. ALKBH5, as an m 6 A …

Mutations in the SMARCA4/BRG1 gene resulting in complete loss of its protein (BRG1)
occur frequently in non-small cell lung cancer (NSCLC) cells. Currently, no single …

A major key to improvement of cancer therapy is the combination of drugs. Mixing drugs that
already exist on the market may offer an attractive alternative. Here we report on a new …

Abstract aurora B kinase is highly expressed in several cancer cells and promotes
tumorigenesis and progression, and therefore, it is an important target for drug to treat …

Cancer immunotherapy has shown impressive results, but most patients do not respond. We
hypothesized that the effector response in the tumour could be visualized as a complex …

Tanshinone is the liposoluble constituent of Salia miltiorrhiza, a root used in traditional
herbal medicine which is known to possess certain health benefits. Although it is known that …

Abstract The Aurora kinase family (Aurora A, B and C) are crucial regulators of several
mitotic events, including cytokinesis. Increased expression of these kinases is associated …

MK-0457, an Aurora kinase and BCR–ABL inhibitor, was studied on a Phase I/II study in 77
patients with refractory hematologic malignancies. The average number of cycles per patient …