Lung cancer is the leading cause of cancer-related death across the world. Unlike lung
adenocarcinoma, patients with lung squamous cell carcinoma (LSCC) have not benefitted …

The transcription factor SOX2 is essential for embryonic development and plays a crucial
role in maintaining the stemness of embryonic cells and various adult stem cell populations …

SOX2 is a well-characterized pluripotent factor that is essential for stem cell self-renewal,
reprogramming, and homeostasis. The cellular levels of SOX2 are precisely regulated by a …

Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …

SOX2 is a gene that encodes for a transcription factor belonging to the SOX gene family and
contains a high-mobility group (HMG) domain, which permits highly specific DNA binding …

The pluripotency-associated transcription factor SOX2 is essential during mammalian
embryogenesis and later in life, but SOX2 expression can also be highly detrimental. Over …

Abstract The Epidermal Growth Factor Receptor (EGFR) is frequently expressed at elevated
levels in different forms of cancer and expression often correlates positively with cancer …

Melanoma is one of the most aggressive types of human cancer, characterized by enhanced
heterogeneity and resistance to conventional therapy at advanced stages. We and others …

Abstract The transcription factor Yin Yang 1 (YY1) is frequently overexpressed in cancerous
tissues compared to normal tissues and has regulatory roles in cell proliferation, cell …

Background Transmembrane serine protease 4 (TMPRSS4) is a cell surface–anchored
serine protease. Elevated expression of TMPRSS4 correlates with poor prognosis in …