Tumors are unique and complex ecosystems, in which heterogeneous cell subpopulations
with variable molecular profiles, aggressiveness, and proliferation potential coexist and …

Whole exome sequencing (WES) enables the analysis of all protein coding sequences in
the human genome. This technology enables the investigation of cancer-related genetic …

Cancer progression is an evolutionary process. During this process, evolving cancer cell
populations encounter restrictive ecological niches within the body, such as the primary …

How and when tumoral clones start spreading to surrounding and distant tissues is currently
unclear. Here we leveraged a model-based evolutionary framework to investigate the …

Understanding intratumor heterogeneity is critical for studying tumorigenesis and designing
personalized treatments. To decompose the mixed cell population in a tumor, subclones are …

Current pre-clinical models of cancer fail to recapitulate the cancer cell behavior in primary
tumors primarily because of the lack of a deeper understanding of the effects that the …

Cancer cell genomes change continuously due to mutations, and mutational processes
change over time in patients, leaving dynamic signatures in the accumulated genomic …

Intratumour heterogeneity provides tumours with the ability to adapt and acquire treatment
resistance. The development of more effective and personalised treatments for cancers …

Tumors harbor extensive genetic heterogeneity in the form of distinct clone genotypes that
arise over time and across different tissues and regions in cancer. Many computational …

Integration of ecological and evolutionary features has begun to understand the interplay of
tumor heterogeneity, microenvironment, and metastatic potential. Developing a theoretical …