Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus
characterized clinically by symptoms related to esophageal dysfunction and histologically by …

Eosinophils are circulating granulocytes that have pleiotropic effects in response to
inflammatory signals in the body. In response to allergens or pathogens, exposure …

The current report describes a stepwise mechanistic pathway of NLRP3/caspase1/IL-18-
regulated immune responses operational in eosinophilic esophagitis (EoE). We show that …

Originally described as an interferon (IFN)-γ-inducing factor, interleukin (IL)-18 has been
reported to be involved in Th1 and Th2 immune responses, as well as in activation of NK …

The prevalence of allergic conditions has continuously increased in the last few decades in
Westernized countries. A dysbiotic gut microbiome may play an important role in the …

Abstract Interleukin (IL)-18 is an IL-1 family cytokine expressed by macrophages, dendritic
cells, epithelial cells, and keratinocytes and is implicated in various aspects of both the …

Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus
associated with an atopic predisposition which appears to be increasing in prevalence over …

Eosinophilic esophagitis (EoE) is an antigen-driven disease associated with epithelial
barrier dysfunction and chronic type 2 inflammation. Eosinophils are the defining feature of …

Eosinophilic esophagitis (EoE) is a relatively new condition described as an allergic-
mediated disease of the esophagus. Clinically, it is characterized by dysphagia, food …

Mast cells appear to play a key role in eosinophilic esophagitis and serve as a biomarker of
mucosal healing in conjunction with eosinophils. Excessive mast cell activation likely …