Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …

Extensive injury of endothelial cells in blood vasculature, especially in the microcirculatory
system, frequently occurs in hosts suffering from sepsis and the accompanied systemic …

Spinal cord injury (SCI) causes immune dysfunction, increasing the risk of infectious
morbidity and mortality. Since bone marrow hematopoiesis is essential for proper immune …

Sepsis remains the single most common cause of mortality and morbidity in hospitalized
patients requiring intensive care. Although earlier detection and improved treatment bundles …

Abstract ETS variant 6 (ETV6) encodes a transcriptional repressor expressed in
hematopoietic stem and progenitor cells (HSPCs), where it is required for adult …

New therapeutic strategies to reduce sepsis-related mortality are urgently needed, as sepsis
accounts for one in five deaths worldwide. Since hematopoietic stem and progenitor cells …

Hematopoietic stem/progenitor cells (HSPC) have both unique and common responses
following hemorrhage, injury, and sepsis. HSPCs from different lineages have a distinctive …

A population of small stem cells with diameters of up to 5 μm resembling very small
embryonic-like stem cells (VSELs) were sorted from human embryonic stem cell (hESC) …

Sepsis survivors suffer from increased vulnerability to infections, and lymphopenia
presumably contributes to this problem. The mechanisms of the recovery of memory CD4+ T …

Cardiometabolic diseases and cancer are among the most common diseases worldwide
and are a serious concern to the healthcare system. These conditions, apparently distant …