Studies in mice and humans have revealed intriguing associations between host genetics
and the microbiome. Here we report a 16S rRNA-based analysis of the gut microbiome in …

As it is likely that both common and rare genetic variation are important for complex disease
risk, studies that examine the full range of the allelic frequency distribution should be utilized …

Anthracycline-induced cardiotoxicity (ACT) is a key limiting factor in setting optimal
chemotherapy regimes, with almost half of patients expected to develop congestive heart …

Complex interactive test items are becoming more widely used in assessments. Being
computer-administered, assessments using interactive items allow logging time-stamped …

In humans, most germline mutations are inherited from the father. This observation has been
widely interpreted as reflecting the replication errors that accrue during spermatogenesis. If …

Motivation Very low-depth sequencing has been proposed as a cost-effective approach to
capture low-frequency and rare variation in complex trait association studies. However, a full …

Background The degree to which host genetic variation can modulate microbial
communities in humans remains an open question. Here, we performed a genetic mapping …

Nuclear envelope proteins have been shown to play an important role in the pathogenesis
of inherited dilated cardiomyopathy. Here, we present a remarkable cardiac phenotype …

Fertility traits in humans are heritable, however, little is known about the genes that influence
reproductive outcomes or the genetic variants that contribute to differences in these traits …

Motivation Despite the need for separate tools to analyze family-based data, there are only a
handful of tools optimized for family-based big data compared to the number of tools …