The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion
patterns and effector functions provides a framework for understanding the heterogeneity of …

The immune system is an organization of cells and molecules with specialized roles in
defending against infection. There are two fundamentally different types of responses to …

How negative selection shapes a polyclonal population of self-reactive T cells has been
difficult to address directly because of the lack of means to isolate T cells reactive to a …

Tumor-specific immune tolerance limits the effectiveness of cancer vaccines. In addition,
tumor vaccines alone have a limited potential for the treatment of measurable tumor …

Immune thrombocytopaenic purpura (ITP) is an autoimmune bleeding disease that is rarely
fatal. However, in many adults treatment is unsatisfactory, with as much morbidity from the …

Galectins are members of a highly conserved family of β-galactoside-binding animal lectins.
Presently, more than 14 members have been identified and additional homologues are …

This third edition is an update on every conceivable aspect of the modern-day management
of contact dermatitis. Both irritant and allergic contact dermatitis are covered clearly and …

Distinct and evolutionarily conserved signal transduction cascades mediate survival or
death in response to developmental and environmental cues. The stress-activated protein …

Signals derived from antigen-presenting cells (APC) influence the functional differentiation
of CD4+ T cells. We report here that Serrate1 (Jagged1), a ligand for the Notch1 receptor …

Allergenicity depends on several factors determined by the very physicochemical nature of
the molecules themselves, ie, their capacity to penetrate the horny layer, lipophilicity, and …