The metabolic stress occurring in the tumor microenvironment (TME) hampers T cell anti-
tumor immunity by disturbing T cell metabolic and epigenetic programs. Recent studies are …

Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …

Background Cancer patients can achieve dramatic responses to chemotherapy yet retain
resistant tumor cells, which ultimately results in relapse. Although xenograft model studies …

The first consensus guidelines for scoring the histopathological growth patterns (HGPs) of
liver metastases were established in 2017. Since then, numerous studies have applied …

Background Oxidative stress is a highly active metabolic process in the liver, that poses
great threats to disseminated tumor cells during their colonization. Here, we aimed to …

Aims EMT is the process by which a polarized epithelial cell undergoes several changes
leading to highly invasive and fibroblast-like morphology. It has been described that miR …

Rationale: Metastasis, the development of secondary malignant growth at a distance from a
primary tumor, is the main cause of cancer-associated death. However, little is known about …

Tumors are equipped with a highly complex machinery of interrelated events so as to adapt
to hazardous conditions, preserve a growing cell mass and thrive at the site of metastasis …

Primary liver cancer is the fifth most common malignancy and the third leading cause of
cancer death worldwide. Although current advances in the treatment of liver cancer, the …

Diffuse-type gastric cancer (DGC) and intestinal-type gastric cancer (IGC) are the major
histological types of gastric cancer (GC). The molecular mechanism underlying DGC and …