High density lipoproteins: metabolism, function, and therapeutic potential

A Jomard, E Osto - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
High Density Lipoproteins (HDLs) have long been considered as “good cholesterol,”
beneficial to the whole body and, in particular, to cardio-vascular health. However, HDLs are …

Coagulatory defects in type-1 and type-2 diabetes

AIS Sobczak, AJ Stewart - International journal of molecular sciences, 2019 - mdpi.com
Diabetes (both type-1 and type-2) affects millions of individuals worldwide. A major cause of
death for individuals with diabetes is cardiovascular diseases, in part since both types of …

The triglyceride/HDL ratio as a surrogate biomarker for insulin resistance

P Baneu, C Văcărescu, SR Drăgan, L Cirin… - …, 2024 - pmc.ncbi.nlm.nih.gov
Given the widespread occurrence of insulin resistance, a key factor in metabolic syndrome
and a distinct condition altogether, there is a clear need for effective, surrogate markers. The …

High-density lipoprotein (HDL) triglyceride and oxidized HDL: new lipid biomarkers of lipoprotein-related atherosclerotic cardiovascular disease

F Ito, T Ito - Antioxidants, 2020 - mdpi.com
Lipid markers are well-established predictors of vascular disease. The most frequently
measured lipid markers are total cholesterol, high-density lipoprotein (HDL)-cholesterol …

Altered triglyceride glucose index and fasted serum triglyceride high‐density lipoprotein cholesterol ratio predict incidence of cardiovascular disease in the Mashhad …

H Mirshafiei, S Darroudi, M Ghayour‐Mobarhan… - …, 2022 - Wiley Online Library
The triglyceride glucose (TyG) index and triglyceride/high lipoprotein density cholesterol
(TG/HDL‐C) are two important risk markers to evaluate the insulin resistance and …

A current update on the role of HDL-based nanomedicine in targeting macrophages in cardiovascular disease

A Rani, G Marsche - Pharmaceutics, 2023 - mdpi.com
High-density lipoproteins (HDL) are complex endogenous nanoparticles involved in
important functions such as reverse cholesterol transport and immunomodulatory activities …

Oxidative stress, atherogenic dyslipidemia, and cardiovascular risk

J Vekic, K Stromsnes, S Mazzalai, A Zeljkovic, M Rizzo… - Biomedicines, 2023 - mdpi.com
Oxidative stress is the consequence of an overproduction of reactive oxygen species (ROS)
that exceeds the antioxidant defense mechanisms. Increased levels of ROS contribute to the …

Using serum metabolomics to predict development of anti-drug antibodies in multiple sclerosis patients treated with IFNβ

KE Waddington, A Papadaki, L Coelewij… - Frontiers in …, 2020 - frontiersin.org
Background: Neutralizing anti-drug antibodies (ADA) can greatly reduce the efficacy of
biopharmaceuticals used to treat patients with multiple sclerosis (MS). However, the …

Causal relationship between gut microbiota, plasma metabolites, inflammatory cytokines and abdominal aortic aneurysm: a Mendelian randomization study

C Li, Z Liu, S Yang, W Li, B Liang, H Chen… - Clinical and …, 2024 - Taylor & Francis
Background Complex interconnections are evident among gut microbiota, circulating
metabolites, inflammatory cytokines, and the pathogenesis of abdominal aortic aneurysms …

The Impact of the Mediterranean Diet and Lifestyle Intervention on Lipoprotein Subclass Profiles among Metabolic Syndrome Patients: Findings of a Randomized …

B Candás-Estébanez, B Fernández-Cidón… - International Journal of …, 2024 - mdpi.com
Metabolic syndrome (MetS) is associated with alterations of lipoprotein structure and
function that can be characterized with advanced lipoprotein testing (ADLT). The effect of the …