Heparin has been used extensively as an antithrombotic and anticoagulant for close to 100
years. This anticoagulant activity is attributed mainly to the pentasaccharide sequence …

Heparin has been recognized as a valuable anticoagulant and antithrombotic for several
decades and is still widely used in clinical practice for a variety of indications. The …

Pregnancy causes significant metabolic and hemodynamic changes in a woman's
physiology to allow for fetal growth. The inability to adapt to these changes might result in …

In a normal pregnancy, maternal circulatory system presents a hypercoagulable state due to
the effect of hormone secretion. Even minor variations in fibrinolytic system could lead to …

Heparin is a life-saving drug, which belongs to few clinically used drugs without defined
molecular structures in modern medicine. Heparin is the mostly negatively charged …

Background Venous thromboembolism (VTE), although rare, is a major cause of maternal
mortality and morbidity. Some women are at increased risk of VTE during pregnancy and the …

Three decades ago, antiphospholipid antibodies (aPL) were proposed to have a causal
association with recurrent pregnancy loss (RPL), suspected because of placental clots that …

Despite the increase in assisted reproductive technologies, the high rates of infertility and
pregnancy complications are a major concern to infertility specialists worldwide. Infertility …

In recent decades, heparin, as the most important anticoagulant drug, has been widely used
in clinical settings to prevent and treat thrombosis in a variety of diseases. However, with in …

A fine balance between coagulation and fibrinolysis is critical in early pregnancy.
Plasminogen activator inhibitor-1 (PAI-1) and angiotensin converting enzyme (ACE) are …